ArticleCartilage2015
A Stereological Method for the Quantitative Evaluation of Cartilage Repair Tissue.
Article in Cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- The power of tendon autograft in osteochondral defects: one step closer to hyaline cartilage.Journal of orthopaedic surgery and research · 2025Article
- Probiotic effects on cognitive performance, hippocampal oxidative stress, and structural damage induced by icv STZ in Alzheimer-like rat model.Brain structure & function · 2025Article
- Increased vascularization of the subchondral region in human osteoarthritic femoral head in the elderly.Histochemistry and cell biology · 2025Article
- Reduced Tumor Volume and Increased Necrosis of Human Breast Tumor Xenograft in Mice Pretreated by a Cocktail of Three Specific Anti-HER2 scFvs.Current protein & peptide science · 2024Article
- An Assessment of Blood Vessel Remodeling of Nanofibrous Poly(ε-Caprolactone) Vascular Grafts in a Rat Animal Model.Journal of functional biomaterials · 2023Article
- A preliminary evaluation of in vivo response to a filament-wound macroporous collagen midurethral sling in an ovine model.Journal of biomedical materials research. Part B, Applied biomaterials · 2022Article
- Effect of fibrin glue on the healing efficacy of deproteinized bovine bone and autologous bone in critical-sized calvarial defects in rats.Clinical oral investigations · 2022Article
- No Effect of Platelet-Rich Plasma Injections as an Adjuvant to Autologous Cartilage Chips Implantation for the Treatment of Chondral Defects.Cartilage · 2021Article
- Mesenchymal Stem Cell Extracellular Vesicles as Adjuvant to Bone Marrow Stimulation in Chondral Defect Repair in a Minipig Model.Cartilage · 2021Article
- Combined Bone Marrow Aspirate and Platelet-Rich Plasma for Cartilage Repair: Two-Year Clinical Results.Cartilage · 2021Article
- Autologous cartilage and fibrin sealant may be superior to conventional fat grafting in preventing physeal bone bridge formation - a pilot study in porcines.Journal of children's orthopaedics · 2020Article
- CARGEL Bioscaffold improves cartilage repair tissue after bone marrow stimulation in a minipig model.Journal of experimental orthopaedics · 2020Article
- Biocompatible chitosan-collagen-hydroxyapatite nanofibers coated with platelet-rich plasma for regenerative engineering of the rotator cuff of the shoulder.RSC advances · 2019Article
- Article
- Omegaven Improves Skin Morphometric Indices in Diabetic Rat Model Wound Healing.The journal of the American College of Clinical Wound Specialists · 2017Article
- Collagen Type IV and Laminin Expressions during Cartilage Repair and in Late Clinically Failed Repair Tissues from Human Subjects.Cartilage · 2016Article
- Does Retrograde Femoral Nailing through a Normal Physis Impair Growth? An Experimental Porcine Model.Strategies in trauma and limb reconstructionArticle
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo implement stereological principles to develop an easy applicable algorithm for unbiased and quantitative evaluation of cartilage repair.
designDesign-unbiased sampling was performed by systematically sectioning the defect perpendicular to the joint surface in parallel planes providing 7 to 10 hematoxylin-eosin stained histological sections. Counting windows were systematically selected and converted into image files (40-50 per defect). The quantification was performed by two-step point counting: (1) calculation of defect volume and (2) quantitative analysis of tissue composition. Step 2 was performed by assigning each point to one of the following categories based on validated and easy distinguishable morphological characteristics: (1) hyaline cartilage (rounded cells in lacunae in hyaline matrix), (2) fibrocartilage (rounded cells in lacunae in fibrous matrix), (3) fibrous tissue (elongated cells in fibrous tissue), (4) bone, (5) scaffold material, and (6) others. The ability to discriminate between the tissue types was determined using conventional or polarized light microscopy, and the interobserver variability was evaluated.
resultsWe describe the application of the stereological method. In the example, we assessed the defect repair tissue volume to be 4.4 mm(3) (CE = 0.01). The tissue fractions were subsequently evaluated. Polarized light illumination of the slides improved discrimination between hyaline cartilage and fibrocartilage and increased the interobserver agreement compared with conventional transmitted light.
conclusionWe have applied a design-unbiased method for quantitative evaluation of cartilage repair, and we propose this algorithm as a natural supplement to existing descriptive semiquantitative scoring systems. We also propose that polarized light is effective for discrimination between hyaline cartilage and fibrocartilage.
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