Evidence map›Paper›PMID 26069714›Full record

ArticleCartilage2015

T1ρ Dispersion in Articular Cartilage: Relationship to Material Properties and Macromolecular Content.

Kathryn E Keenan, Thor F Besier, John M Pauly, R Lane Smith, Scott L Delp, Gary S Beaupre, Garry E Gold

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. SPICY: a method for single scan rotating frame relaxometry.Physical chemistry chemical physics : PCCP · 2023
    Article
  2. Article
  3. Embedded Quantitative MRI TJournal of imaging · 2022
    Article
  4. Article
  5. Article
  6. TQuantitative imaging in medicine and surgery · 2019
    Article
  7. Review
  8. Article
  9. Composite metric RJournal of orthopaedic research : official publication of the Orthopaedic Research Society · 2017
    Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kathryn E KeenanDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA.
Thor F BesierAuckland Bioengineering Institute, University of Auckland, Auckland, New Zealand.
John M PaulyMagnetic Resonance Systems Research Laboratory, Department of Electrical Engineering, Stanford University, Stanford, CA, USA.
R Lane SmithDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA ; Rehabilitation R&D Musculoskeletal Research Laboratory, Department of Veterans Affairs, Palo Alto, CA, USA.
Scott L DelpDepartment of Mechanical Engineering, Stanford University, Stanford, CA, USA ; Department of Bioengineering, Stanford University, Stanford, CA, USA.
Gary S BeaupreRehabilitation R&D Musculoskeletal Research Laboratory, Department of Veterans Affairs, Palo Alto, CA, USA.
Garry E GoldDepartment of Orthopaedic Surgery, Stanford University, Stanford, CA, USA ; Department of Bioengineering, Stanford University, Stanford, CA, USA ; Department of Radiology, Stanford University, Stanford, CA, USA.

Funding

Rapid MRI for Evaluation of OsteoarthritisR01EB002524 · NIBIB · STANFORD UNIVERSITY · PI Akshay Chaudhari, Garry E Gold · 2003 to 2026
$10.1M
Real-Time MRI and 3D Modeling: Development &ApplicationR01EB005790 · NIBIB · STANFORD UNIVERSITY · PI GOLD, GARRY E · 2005 to 2008
$1.5M
Characterizing Patellofemoral Joint Stress Using Patient-Specific ModelsI01RX000590 · VA · VETERANS ADMIN PALO ALTO HEALTH CARE SYS · PI BEAUPRE, GARY · 2012 to 2014
–
NIBIB NIH HHS R01 EB002524NIBIB NIH HHS R01 EB005790RRD VA I01 RX000590
6 · The paper itself

Abstract

objectiveThis study assessed T1ρ relaxation dispersion, measured by magnetic resonance imaging (MRI), as a tool to noninvasively evaluate cartilage material and biochemical properties. The specific objective was to answer two questions: (1) does cartilage initial elastic modulus (E 0) correlate with T1ρ dispersion effects and (2) does collagen or proteoglycan content correlate with T1ρ dispersion effects?

designCadaveric patellae with and without visible cartilage damage on conventional MR were included. T2 and T1ρ relaxation times at 500 and 1000 Hz spin-lock field amplitudes were measured. We estimated T1ρ dispersion effects by measuring T1ρ relaxation time at 500 and 1000 Hz and T2 relaxation time and using a new tool, the ratio T1ρ/T2. Cartilage initial elastic modulus, E 0, was measured from initial response of mechanical indentation creep tests. Collagen and proteoglycan contents were measured at the indentation test sites; proteoglycan content was measured by their covalently linked sulfated glycosaminoglycans (sGAG). Pearson correlation coefficients were determined, taking into account the clustering of multiple samples within a single patella specimen.

resultsCartilage initial elastic modulus, E 0, increased with decreasing values of T1ρ/T2 measurements at both 500 Hz (P = 0.034) and 1000 Hz (P = 0.022). 1/T1ρ relaxation time (500 Hz) increased with increasing sGAG content (P = 0.041).

conclusionsT1ρ/T2 ratio, a new tool, and cartilage initial elastic modulus are both measures of water-protein interactions, are dependent on the cartilage structure, and were correlated in this study.

Indexed as

articular cartilagecollageninitial elastic modulusproteoglycanT1ρ dispersion

Identifiers

PMID26069714
PMCPMC4462251

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.