ArticleCartilage2012
The Augmentation of a Collagen/Glycosaminoglycan Biphasic Osteochondral Scaffold with Platelet-Rich Plasma and Concentrated Bone Marrow Aspirate for Osteochondral Defect Repair in Sheep: A Pilot Study.
Article in Cartilage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
20 citing papers in PubMed, 38 citations in OpenAlex.
- 3D printed Bouncy Bioglass enhances articular cartilage regeneration.Bioactive materials · 2027Article
- Models of cartilage repair with autologous mesenchymal stem cells seeded on scaffolds: a systematic narrative review.Frontiers in bioengineering and biotechnology · 2026Review
- Key considerations on the development of biodegradable biomaterials for clinical translation of medical devices: With cartilage repair products as an example.Bioactive materials · 2022Review
- Effect of Platelet-Rich Plasma on Autologous Chondrocyte Implantation for Chondral Defects: Results Using an In Vivo Rabbit Model.Orthopaedic journal of sports medicine · 2022Article
- Articular cartilage and osteochondral tissue engineering techniques: Recent advances and challenges.Bioactive materials · 2021Review
- Sheep condyle model evaluation of bone marrow cell concentrate combined with a scaffold for repair of large osteochondral defects.Bone & joint research · 2021Article
- Small Ruminant Models for Articular Cartilage Regeneration by Scaffold-Based Tissue Engineering.Stem cells international · 2021Review
- Scaffold-Based Tissue Engineering Strategies for Osteochondral Repair.Frontiers in bioengineering and biotechnology · 2021Review
- [Chondrocyte cocultures with stromal vascular fraction of adipose tissue promote cartilage regeneration in vivo].Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology · 2020Article
- Chondrocyte Co-cultures with the Stromal Vascular Fraction of Adipose Tissue in Polyhydroxybutyrate/Poly-(hydroxybutyrate-co-hydroxyhexanoate) Scaffolds: Evaluation of Cartilage Repair in Rabbit.Cell transplantation · 2019Article
- Mesenchymal stem cell-loaded porous tantalum integrated with biomimetic 3D collagen-based scaffold to repair large osteochondral defects in goats.Stem cell research & therapy · 2019Article
- Treatment of Focal Cartilage Defects in Minipigs with Zonal Chondrocyte/Mesenchymal Progenitor Cell Constructs.International journal of molecular sciences · 2019Article
- Article
- "Patient reported outcomes" following experimental surgery-using telemetry to assess movement in experimental ovine models.Journal of orthopaedic research : official publication of the Orthopaedic Research Society · 2018Article
- The Good the Bad and the Ugly of Glycosaminoglycans in Tissue Engineering Applications.Pharmaceuticals (Basel, Switzerland) · 2017Review
- Repair of osteochondral defects with in vitro engineered cartilage based on autologous bone marrow stromal cells in a swine model.Scientific reports · 2017Article
- Article
- Bone Marrow Aspirate Concentrate-Enhanced Marrow Stimulation of Chondral Defects.Stem cells international · 2017Review
- Peripheral Blood Mononuclear Cells Enhance Cartilage Repair in in vivo Osteochondral Defect Model.PloS one · 2015Article
- Alterations in sclerostin protein in lesions of equine osteochondrosis.Veterinary record open · 2014Article
Corrections and comments
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Authors and funding
7 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study investigates the combination of platelet-rich plasma (PRP) or concentrated bone marrow aspirate (CBMA) with a biphasic collagen/glycosaminoglycan (GAG) osteochondral scaffold for the treatment of osteochondral defects in sheep.
designAcute osteochondral defects were created in the medial femoral condyle (MFC) and the lateral trochlea sulcus (LTS) of 24 sheep (n = 6). Defects were left empty or filled with a 6 × 6-mm scaffold, either on its own or in combination with PRP or CBMA. Outcome measures at 6 months included mechanical testing, International Cartilage Repair Society (ICRS) repair score, modified O'Driscoll histology score, qualitative histology, and immunohistochemistry for type I, II, and VI collagen.
resultsNo differences in mechanical properties, ICRS repair score, or modified O'Driscoll score were detected between the 4 groups. However, qualitative assessments of the histological architecture, Safranin O content, and collagen immunohistochemistry indicated that in the PRP/scaffold groups, there was a more hyaline cartilage-like tissue repair. In addition, the addition of CBMA and PRP to the scaffold reduced cyst formation in the subchondral bone of healed lesions.
conclusionThere was more hyaline cartilage-like tissue formed in the PRP/scaffold group and less subchondral cystic lesion formation in the CBMA and PRP/scaffold groups, although there were no quantitative differences in the repair tissue formed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.