Evidence map›Paper›PMID 26069617›Full record

ArticleCartilage2012

One-Year Clinical and Radiological Results of a Prospective, Investigator-Initiated Trial Examining a Novel, Purely Autologous 3-Dimensional Autologous Chondrocyte Transplantation Product in the Knee.

Stefan Fickert, Philip Gerwien, Benjamin Helmert, Torsten Schattenberg, Sabine Weckbach, Marietta Kaszkin-Bettag, Lars Lehmann

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed, 1 synthesis or guideline pooled it, 51 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Good clinical and MRI outcome after arthroscopic autologous chondrocyte implantation for cartilage repair in the knee.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2018
    Trial
  4. Review
  5. Review
  6. Hyperplastic Human Macromass Cartilage for Joint Regeneration.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Review
  18. Article
  19. Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Stefan FickertOrthopaedic and Trauma Surgery Center, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Philip GerwienOrthopaedic and Trauma Surgery Center, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Benjamin HelmertOrthopaedic and Trauma Surgery Center, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Torsten SchattenbergOrthopaedic and Trauma Surgery Center, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
Sabine WeckbachDepartment of Clinical Radiology, University Hospital Munich-Grosshadern Campus, Munich, Germany.
Marietta Kaszkin-BettagPharmaLex GmbH, Mannheim, Germany.
Lars LehmannOrthopaedic and Trauma Surgery Center, University Medical Center Mannheim, University of Heidelberg, Mannheim, Germany.
University Medical Centre Mannheim · DEMünchen Klinik · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe 3-dimensional autologous chondrocyte transplantation (ACT3D) comprises isolation of chondrocytes from cartilage biopsies, cultivation to spheroids, and transplantation into the cartilage defect.

objectivesTo evaluate the patients' general health and functionality and to assess the defect repair after ACT3D with spheroids by MRI and MOCART scoring.

methodsThirty-seven patients with isolated chondral lesions of the knee underwent ACT3D with spheroids through medial arthrotomy. Patient-administered scores were assessed at baseline (day before transplantation), at 6 weeks, and at 3, 6, and 12 months. MRI and MOCART scoring were performed at 3 and 12 months after ACT3D.

resultsPatients were diagnosed with full-thickness patellofemoral (n = 16), femoral condylar (n = 18), or both defect types (n = 3), International Cartilage Repair Society (ICRS) grade 3 or 4, with defect sizes between 1.0 and 12.0 cm(2). On average, 59.5 spheroids/cm(2) in defect size were transplanted. An overall statistically significant improvement from baseline to 12 months was observed for all assessment scores (Lysholm, International Knee Documentation Committee [IKDC], SF-36, Tegner) combined with a significant reduction in the visual analog scale (VAS) for pain and an advanced defect filling. Subgroup analyses revealed a positive clinical outcome independent on defect size, defect locations, spheroid dosage, age, duration of symptoms, and severity of complaints at baseline. Seven patients experienced in total 8 adverse events, of which knee joint effusion and blocking were assessed as possibly or probably related to ACT3D.

conclusionsThe patient-administered assessment scores along with the fast defect filling with ACT3D using spheroids demonstrated an increase in activity level and quality of life after a 1-year follow-up.

Indexed as

ACTACT3Dautologous chondrocytescartilage defectIKDCLysholmSF-36spheroidsTegnerVAS

Identifiers

PMID26069617
PMCPMC4297188
OpenAlexW1975247390

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.