Evidence map›Paper›PMID 26069595›Full record

ArticleCartilage2011

Acrylamide Polymer Double-Network Hydrogels: Candidate Cartilage Repair Materials with Cartilage-Like Dynamic Stiffness and Attractive Surgery-Related Attachment Mechanics.

Markus P Arnold, Alma U Daniels, Sarah Ronken, Helena Ardura García, Niklaus F Friederich, Takayuki Kurokawa, Jian P Gong, Dieter Wirz

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 29 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 3 countries.

Markus P ArnoldDepartment of Orthopedic Surgery and Skeletal Traumatology, Kantonsspital Bruderholz, Bruderholz, Switzerland.
Alma U DanielsLaboratory of Biomechanics and Biocalorimetry, Faculty of Medicine, University of Basel, Basel, Switzerland.
Sarah RonkenLaboratory of Biomechanics and Biocalorimetry, Faculty of Medicine, University of Basel, Basel, Switzerland.
Helena Ardura GarcíaBiomedical Engineering Section, Department of Engineering, Universidad Iberoamericana, Mexico City, Mexico.
Niklaus F FriederichDepartment of Orthopedic Surgery and Skeletal Traumatology, Kantonsspital Bruderholz, Bruderholz, Switzerland.
Takayuki KurokawaDepartment of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan ; Creative Research Institution "Sousei", Hokkaido University, Sapporo, Japan.
Jian P GongDepartment of Biological Sciences, Graduate School of Science, Hokkaido University, Sapporo, Japan.
Dieter WirzDepartment of Orthopedic Surgery and Skeletal Traumatology, Kantonsspital Bruderholz, Bruderholz, Switzerland ; Laboratory of Biomechanics and Biocalorimetry, Faculty of Medicine, University of Basel, Basel, Switzerland.
University of Basel · CHHokkaido University · JPKantonsspital Baselland Standort Bruderholz · CHIbero American University · MX

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundIn focal repair of joint cartilage and meniscus, initial stiffness and strength of repairs are generally much less than surrounding tissue. This increases early failure potential. Secure primary fixation of the repair material is also a problem. Acrylamide polymer double-network (DN) hydrogels are candidate-improved repair materials. DN gels have exceptional strength and toughness compared to ordinary gels. This stems from the double-network structure in which there is a high molar ratio of the second network to the first network, with the first network highly crosslinked and the second loosely crosslinked. Previous studies of acrylic PAMPS/PDMAAm and PAMPS/PAAm DN gels demonstrated physicochemical stability and tissue compatibility as well as the ability to foster cartilage formation.

methodsMechanical properties related to surgical use were tested in 2 types of DN gels.

resultsRemarkably, these >90%-water DN gels exhibited dynamic impact stiffness (E*) values (~1.1 and ~1.5 MPa) approaching swine meniscus (~2.9 MPa). Dynamic impact energy-absorbing capability was much lower (median loss angles of ~2°) than swine meniscus (>10°), but it is intriguing that >90%-water materials can efficiently store energy. Also, fine 4/0 suture tear-out strength approached cartilage (~2.1 and ~7.1 N v. ~13.5 N). Initial strength of attachment of DN gels to cartilage with acrylic tissue adhesive was also high (~0.20 and ~0.15 N/mm(2)).

conclusionsDN gel strength and toughness properties stem from optimized entanglement of the 2 network components. DN gels thus have obvious structural parallels with cartilaginous tissues, and their surgical handling properties make them ideal candidates for clinical use.

Indexed as

cartilage repairgelsloss anglemodulussuturing

Identifiers

PMID26069595
PMCPMC4297135
OpenAlexW2167111724

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.