Evidence map›Paper›PMID 26069586›Full record

ArticleCartilage2011

The Fate of Oral Glucosamine Traced by (13)C Labeling in the Dog.

George R Dodge, Ravinder R Regatte, Elizabeth A Noyszewski, Jeffery O Hall, Akella V Sharma, D Allen Callaway, Ravinder Reddy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cartilage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 3 citations in OpenAlex.

  1. Unlocking the Real Potential of Black Soldier Fly (Molecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

George R DodgeDepartment of Biological Sciences, University of Delaware, Newark, DE, USA ; McKay Orthopaedic Research Laboratory, Department of Orthopaedic Surgery, University of Pennsylvania, Philadelphia, PA, USA.
Ravinder R RegatteMMRRCC, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Elizabeth A NoyszewskiMMRRCC, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
Jeffery O HallUtah Veterinary Diagnostic Laboratories, Utah State University, Logan, UT, USA.
Akella V SharmaMMRRCC, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
D Allen CallawayDepartment of Biological Sciences, University of Delaware, Newark, DE, USA.
Ravinder ReddyMMRRCC, Department of Radiology, University of Pennsylvania, Philadelphia, PA, USA.
University of Pennsylvania · USUniversity of Delaware · USUtah State University · US

Funding

EARLY DETECTION OF OSTEOARTHRITISR01AR045242 · NIAMS · UNIVERSITY OF PENNSYLVANIA · PI REDDY, RAVINDER · 1998 to 2004
$1.3M
NIAMS NIH HHS R01 AR045242
6 · The paper itself

Abstract

objectiveIt has remained ambiguous as to whether oral dosing of glucosamine (GlcN) would make its way to the joint and affect changes in the cartilage, particularly the integrity of cartilage and chondrocyte function. The objective of this study was to trace the fate of orally dosed GlcN and determine definitively if GlcN was incorporated into cartilage proteoglycans.

designTwo dogs were treated with (13)C-GlcN-HCl by oral dosing (500 mg/dog/d for 2 weeks and 250 mg/dog/d for 3 weeks). Cartilage was harvested from the tibial plateau and femoral condyles along with tissue specimens from the liver, spleen, heart, kidney, skin, skeletal muscle, lung, and costal cartilage. Percentages of (13)C and (13)C-GlcN present in each tissue sample were determined by inductively coupled plasma mass spectroscopy (ICP-MS) and nuclear magnetic resonance spectroscopy, respectively.

resultsIn the case of dog 1 (2-week treatment), there was an increase of 2.3% of (13)C present in the articular cartilage compared to the control and an increase of 1.6% of (13)C in dog 2 compared to control. As to be expected, the highest percentage of (13)C in the other tissues tested was found in the liver, and the remaining tissues had percentages of (13)C less than that of articular cartilage.

conclusionThe results are definitive and for the first time provide conclusive evidence that orally given GlcN can make its way through the digestive tract and be used by chondrocytes in joint cartilage, thereby potentially having an effect on the available GlcN for proteoglycan biosynthesis.

Indexed as

animal modelsarticular cartilagedrug deliveryosteoarthritis disease modificationtissue

Identifiers

PMID26069586
PMCPMC4300808
OpenAlexW2020288743

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.