ArticleCartilage2011
International Cartilage Repair Society (ICRS) Recommended Guidelines for Histological Endpoints for Cartilage Repair Studies in Animal Models and Clinical Trials.
Article in Cartilage, 2011. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05450458 (Safety and Effectiveness of Hyaluronic Acid and Sorbitol With Overuse Knee Pain in Sportsmen), which is not on this map. Cited by 80 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safety and Effectiveness of Hyaluronic Acid and Sorbitol With Overuse Knee Pain in Sportsmen
Who cites it
80 citing papers in PubMed, 4 syntheses or guidelines pooled it, 158 citations in OpenAlex.
- Histological and Immunohistochemical Methods in Normal and Osteoarthritic Knee Cartilage of Rat and Rabbit Models: A Literature Review.International journal of molecular sciences · 2025Pooled it
- Systematic Comparison of Biomaterials-Based Strategies for Osteochondral and Chondral Repair in Large Animal Models.Advanced healthcare materials · 2021Pooled it
- A Systematic Review and Guide to Mechanical Testing for Articular Cartilage Tissue Engineering.Tissue engineering. Part C, Methods · 2019Pooled it
- What is the effect of matrices on cartilage repair? A systematic review.Clinical orthopaedics and related research · 2015Pooled it
- Routine MRI Signal Intensity as a Surrogate of Subchondral Bone Healing: Validation Against Micro-CT and Histology in an Ovine Model.Diagnostics (Basel, Switzerland) · 2026Article
- Radiologic and Clinical Analysis of Posterior Medial Meniscal Root Tears: A Comparative Study of All-Suture Anchor and Transtibial Pullout Techniques.Orthopaedic journal of sports medicine · 2026Article
- The Effect of Curcumin Treatment on Healing in a Rat Distal Femoral Osteochondral Defect Model.Cartilage · 2026Article
- 27-Week avocado-soybean unsaponifiables treatment in a knee osteoarthritis rabbit model: histomorphometric assessment of potential disease-modifying effects.Frontiers in veterinary science · 2026Article
- Evaluation of Engineered Cartilage Composition and Function Using Raman Spectroscopy.Advanced healthcare materials · 2025Article
- Bone marrow lesion and medial meniscus extrusion width changes following arthroscopic partial meniscectomy for medial meniscal flap tears.Journal of orthopaedic surgery and research · 2025Article
- Optimized Lipid Nanoparticle-Mediated mRNA Co-Delivery of SOX5/SOX9 Enables Synergistic Senescence Reversal for Osteoarthritis Therapy.International journal of nanomedicine · 2025Article
- Effect of collagen-based scaffolds with hydroxyapatite on the repair of cartilage defects in the rabbit knee joint.Journal of orthopaedic surgery and research · 2024Article
- Collection, Establishment and Assessment of Complex Human Osteocartilaginous Explants for Modeling Osteoarthritis.Biomedicines · 2024Article
- [Treatment of osteochondritis dissecans].Orthopadie (Heidelberg, Germany) · 2024Article
- Effectiveness of Bilayer Scaffold Containing Chitosan/Gelatin/Diclofenac and Bovine Hydroxyapatite on Cartilage/Subchondral Regeneration in Rabbit Joint Defect Models.Advances in pharmacological and pharmaceutical sciences · 2024Article
- Orthotopic equine study confirms the pivotal importance of structural reinforcement over the pre-culture of cartilage implants.Bioengineering & translational medicine · 2024Article
- Applying additional autologous platelet-rich fibrin matrix or serial platelet-rich plasma to microfracture technique increases the quality of the repaired cartilage.Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA · 2023Article
- Immunohistochemical Analysis of Knee Chondral Defect Repair after Autologous Particulated Cartilage and Platelet-Rich Plasma Treatment in Sheep.International journal of molecular sciences · 2023Article
- Regenerative Effect of Mesenchymal Stem Cell on Cartilage Damage in a Porcine Model.Biomedicines · 2023Article
- Pharmacological Functions, Synthesis, and Delivery Progress for Collagen as Biodrug and Biomaterial.Pharmaceutics · 2023Review
20 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 6 institutions in 3 countries.
Funding
Abstract
Cartilage repair strategies aim to resurface a lesion with osteochondral tissue resembling native cartilage, but a variety of repair tissues are usually observed. Histology is an important structural outcome that could serve as an interim measure of efficacy in randomized controlled clinical studies. The purpose of this article is to propose guidelines for standardized histoprocessing and unbiased evaluation of animal tissues and human biopsies. Methods were compiled from a literature review, and illustrative data were added. In animal models, treatments are usually administered to acute defects created in healthy tissues, and the entire joint can be analyzed at multiple postoperative time points. In human clinical therapy, treatments are applied to developed lesions, and biopsies are obtained, usually from a subset of patients, at a specific time point. In striving to standardize evaluation of structural endpoints in cartilage repair studies, 5 variables should be controlled: 1) location of biopsy/sample section, 2) timing of biopsy/sample recovery, 3) histoprocessing, 4) staining, and 5) blinded evaluation with a proper control group. Histological scores, quantitative histomorphometry of repair tissue thickness, percentage of tissue staining for collagens and glycosaminoglycan, polarized light microscopy for collagen fibril organization, and subchondral bone integration/structure are all relevant outcome measures that can be collected and used to assess the efficacy of novel therapeutics. Standardized histology methods could improve statistical analyses, help interpret and validate noninvasive imaging outcomes, and permit cross-comparison between studies. Currently, there are no suitable substitutes for histology in evaluating repair tissue quality and cartilaginous character.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.