ArticleBioscience2014
Ionic Current Variability and Functional Stability in the Nervous System.
Article in Bioscience, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed.
- Modeling synaptic interactions between mammalian breathing and swallowing central pattern generators.Biological cybernetics · 2026Article
- Whole brain fluorescence imaging iniScience · 2026Article
- Modulation by Neuropeptides with Overlapping Targets Results in Functional Overlap in Oscillatory Circuit Activation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Variable task switching in the feeding network ofJournal of neurophysiology · 2023Article
- Gating of homeostatic regulation of intrinsic excitability produces cryptic long-term storage of prior perturbations.Proceedings of the National Academy of Sciences of the United States of America · 2023Article
- Adaptive unscented Kalman filter for neuronal state and parameter estimation.Journal of computational neuroscience · 2023Article
- Thermal acclimation and habitat-dependent differences in temperature robustness of a crustacean motor circuit.Frontiers in cellular neuroscience · 2023Article
- Training spiking neuronal networks to perform motor control using reinforcement and evolutionary learning.Frontiers in computational neuroscience · 2022Article
- From the Neuroscience of Individual Variability to Climate Change.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Article
- Accounting for variability in ion current recordings using a mathematical model of artefacts in voltage-clamp experiments.Philosophical transactions. Series A, Mathematical, physical, and engineering sciences · 2020Article
- Network Degeneracy and the Dynamics of Task Switching in the Feeding Circuit inThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2019Article
- Dimensions of control for subthreshold oscillations and spontaneous firing in dopamine neurons.PLoS computational biology · 2019Article
- Article
- The Dynamic Basis of Respiratory Rhythm Generation: One Breath at a Time.Annual review of neuroscience · 2018Review
- Origin of heterogeneous spiking patterns from continuously distributed ion channel densities: a computational study in spinal dorsal horn neurons.The Journal of physiology · 2018Article
- Mechanisms of generation of membrane potential resonance in a neuron with multiple resonant ionic currents.PLoS computational biology · 2017Article
- Genetic perturbations suggest a role of the resting potential in regulating the expression of the ion channels of the KCNA and HCN families in octopus cells of the ventral cochlear nucleus.Hearing research · 2017Article
- The complexity of small circuits: the stomatogastric nervous system.Current opinion in neurobiology · 2016Review
- Consequences of degeneracy in network function.Current opinion in neurobiology · 2016Review
- Dynamic compensation mechanism gives rise to period and duty-cycle level sets in oscillatory neuronal models.Journal of neurophysiology · 2016Article
Corrections and comments
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Authors and funding
1 author.
Funding
Abstract
Identified neurons in different animals express ionic currents at highly variable levels (population variability). If neuronal identity is associated with stereotypical function, as is the case in genetically identical neurons or in unambiguously identified individual neurons, this variability poses a conundrum: How is activity the same if the components that generate it-ionic current levels-are different? In some cases, ionic current variability across similar neurons generates an output gradient. However, many neurons produce very similar output activity, despite substantial variability in ionic conductances. It appears that, in many such cells, conductance levels of one ionic current vary in proportion to the conductance levels of another current. As a result, in a population of neurons, these conductances appear to be correlated. Here, I review theoretical and experimental work that suggests that neuronal ionic current correlation can reduce the global ionic current variability and can contribute to functional stability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.