ArticleDrug delivery and translational research2015
Enhanced skin delivery of vismodegib by microneedle treatment.
Article in Drug delivery and translational research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
16 citing papers in PubMed.
- Hydrogel-Forming Microneedles in the Management of Dermal Disorders Through a Non-Invasive Process: A Review.Gels (Basel, Switzerland) · 2024Review
- Polymeric Microneedles Enhance Transdermal Delivery of Therapeutics.Pharmaceutics · 2024Article
- Microneedle-mediated transdermal delivery of N-acetyl cysteine as a potential antidote for lewisite injury.International journal of pharmaceutics · 2023Article
- Microneedle Mediated Iontophoretic Delivery of Tofacitinib Citrate.Pharmaceutical research · 2023Article
- Microneedle-Mediated Transdermal Delivery of Biopharmaceuticals.Pharmaceutics · 2023Review
- Topical Delivery of Hedgehog Inhibitors: Current Status and Perspectives.International journal of molecular sciences · 2022Review
- Microneedle and iontophoresis mediated delivery of methotrexate into and across healthy and psoriatic skin.International journal of pharmaceutics · 2022Article
- Levothyroxine sodium loaded dissolving microneedle arrays for transdermal delivery.ADMET & DMPK · 2022Article
- The Topical Nanodelivery of Vismodegib Enhances Its Skin Penetration and PerformancePharmaceutics · 2021Article
- Article
- Electrically and Ultrasonically Enhanced Transdermal Delivery of Methotrexate.Pharmaceutics · 2018Article
- Three-Dimensional (3D) Printed Microneedles for Microencapsulated Cell Extrusion.Bioengineering (Basel, Switzerland) · 2018Article
- Transdermal delivery of human growth hormone via laser-generated micropores.Drug delivery and translational research · 2018Article
- Delivery of Methotrexate and Characterization of Skin Treated by Fabricated PLGA Microneedles and Fractional Ablative Laser.Pharmaceutical research · 2018Article
- Novel in situ forming hydrogel microneedles for transdermal drug delivery.Drug delivery and translational research · 2017Article
- Fabrication of a Ti porous microneedle array by metal injection molding for transdermal drug delivery.PloS one · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The present study investigated the effects of microneedle treatment (maltose microneedles, Admin Pen™ 1200, and Admin Pen™ 1500) on in vitro transdermal delivery of vismodegib with different needle lengths, skin equilibration times, and microneedle insertion durations. The influence of microneedle treatment on the dimensions of microchannels (dye binding, calcein imaging, histology, and confocal microscopy studies), transepidermal water loss, and skin permeability of vismodegib was also evaluated. Skin viscoelasticity was assessed using a rheometer, and microneedle geometry was characterized by scanning electron microscopy. Permeation studies of vismodegib through dermatomed porcine ear skin were conducted using vertical Franz diffusion cells. Skin irritation potential of vismodegib formulation was assessed using an in vitro reconstructed human epidermis model. Results of the in vitro permeation studies revealed significant enhancement in permeation of vismodegib through microneedle-treated skin. As the needle length increased from 500 to 1100 and 1400 μm, drug delivery increased from 14.50 ± 2.35 to 32.38 ± 3.33 and 74.40 ± 15.86 μg/cm(2), respectively. Positive correlation between drug permeability and microneedle treatment duration was observed. The equilibration time was also found to affect the delivery of vismodegib. Thus, changes in microneedle length, equilibration time, and duration of treatment altered transdermal delivery of vismodegib.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.