Evidence map›Paper›PMID 26069102›Full record

ArticleTumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine2015

Regulation of metastasis of bladder cancer cells through the WNT signaling pathway.

Yiheng Du, Yongchuan Wang, Fei Zhang, Wenbo Wu, Wei Wang, Hao Li, Shujie Xia, Haitao Liu

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 18 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Glycoprotein nonmetastatic melanoma protein B accelerates tumorigenesis of cervical cancer in vitro by regulating the Wnt/β-catenin pathway.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2018
    Article
  6. Review
  7. Article
  8. Article
  9. Article
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  12. Take the Wnt out of the inflammatory sails: modulatory effects of Wnt in airway diseases.Laboratory investigation; a journal of technical methods and pathology · 2016
    Review
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Yiheng DuDepartment of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University, 100 Haining Rd, Shanghai, 200080, China.
Yongchuan WangDepartment of Urology, Weifang Hospital of Chinese Traditional Medicine, Weifang, 261041, China.
Fei ZhangDepartment of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University, 100 Haining Rd, Shanghai, 200080, China.
Wenbo WuDepartment of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University, 100 Haining Rd, Shanghai, 200080, China.
Wei WangDepartment of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University, 100 Haining Rd, Shanghai, 200080, China.
Hao LiDepartment of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University, 100 Haining Rd, Shanghai, 200080, China.
Shujie XiaDepartment of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University, 100 Haining Rd, Shanghai, 200080, China.
Haitao LiuDepartment of Urology, Shanghai First People's Hospital, Shanghai Jiao Tong University, 100 Haining Rd, Shanghai, 200080, China. liuhaitao4@163.com.
Shanghai Jiao Tong University · CNShanghai First People's Hospital · CNWeifang Chinese Medicine Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Bladder cancer (BC) is the most popular malignant urinary cancer, with the highest incidence and mortality of all genitourinary system tumors worldwide. To date, the molecular regulation of the metastasis of BC remains ill defined. Here, we examined the levels of matrix metallopeptidase 9 (MMP9) and nuclear β-catenin in the BC specimen. We used lithium chloride (LiCl) to inhibit cytosol β-catenin phosphorylation and degradation to increase nuclear β-catenin levels in BC cells. We used IWP-2 to enhance cytosol β-catenin phosphorylation and degradation to decrease nuclear β-catenin levels in BC cells. We examined MMP9 levels in these experimental settings by quantitative reverse transcription-PCR (RT-qPCR), Western blot, and ELISA. The cell invasiveness was evaluated by Transwell cell assay. We found significantly higher levels of MMP9 and nuclear β-catenin in human BC specimen with metastasis, compared to those without metastasis. Moreover, a strong correlation was detected between MMP9 and nuclear β-catenin. LiCl significantly increased nuclear β-catenin, resulting in MMP9 activation in BC cells. IWP-2 significantly decreased nuclear β-catenin, resulting in MMP9 inhibition in BC cells. MMP9 regulated cell invasiveness. Together, these data suggest that the WNT signaling pathway regulates metastasis of BC through activation of MMP9. Therapies targeting the WNT signaling pathway may be a promising treatment for BC.

Indexed as

beta CateninCell Line, TumorCell ProliferationGene Expression Regulation, NeoplasticHumansLithium ChlorideMatrix Metalloproteinase 9Neoplasm MetastasisPhosphorylationProteolysisUrinary Bladder NeoplasmsWnt Signaling Pathwaybeta CateninLithium ChlorideMatrix Metalloproteinase 9MMP9 protein, humanBladder cancer (BC)MMP9WNT signalingβ-Catenin

Identifiers

PMID26069102
OpenAlexW604665627

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.