ArticlePloS one2015
Tyrosol Suppresses Allergic Inflammation by Inhibiting the Activation of Phosphoinositide 3-Kinase in Mast Cells.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.
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Who cites it
18 citing papers in PubMed, 1 synthesis or guideline pooled it, 41 citations in OpenAlex.
- Efficacy and safety of three species ofFrontiers in pharmacology · 2023Pooled it
- Exploring the Therapeutic Potential of Tyrosol and its Derivatives: A Comprehensive Review.Current medicinal chemistry · 2025Review
- Oleanolic Acid Acetate Inhibits Mast Cell Activation in Ovalbumin-Induced Allergic Airway Inflammation.Allergy, asthma & immunology research · 2023Article
- Metabolite Chemical Composition of theMycobiology · 2023Article
- Tyrosol improves ovalbumin (OVA)-induced asthma in rat model through prevention of airway inflammation.Naunyn-Schmiedeberg's archives of pharmacology · 2021Article
- Tyrosol as a Neuroprotector: Strong Effects of a "Weak" Antioxidant.Current neuropharmacology · 2021Review
- SG-SP1 Suppresses Mast Cell-Mediated Allergic Inflammation via Inhibition of FcεRI Signaling.Frontiers in immunology · 2020Article
- Article
- Phenotype-Specific Therapeutic Effect ofInternational journal of molecular sciences · 2019Article
- Synthesis of Lipophilic Esters of Tyrosol, Homovanillyl Alcohol and Hydroxytyrosol.Antioxidants (Basel, Switzerland) · 2019Article
- MicroRNA 27b-3p Modulates SYK in Pediatric Asthma Induced by Dust Mites.Frontiers in pediatrics · 2018Article
- Formononetin ameliorates mast cell-mediated allergic inflammation via inhibition of histamine release and production of pro-inflammatory cytokines.Experimental and therapeutic medicine · 2017Article
- Diospyros kaki calyx inhibits immediate-type hypersensitivity via the reduction of mast cell activation.Pharmaceutical biology · 2017Article
- Coumarins from the roots ofExperimental and therapeutic medicine · 2017Article
- 2-Hydroxy-3-methoxybenzoic acid attenuates mast cell-mediated allergic reaction in mice via modulation of the FcεRI signaling pathway.Acta pharmacologica Sinica · 2017Article
- Developing criteria for evaluation of geroprotectors as a key stage toward translation to the clinic.Aging cell · 2016Review
- Furan, phenolic, and heptelidic acid derivatives produced byFood science and biotechnology · 2016Article
- Ethanol Extract of Sanguisorbae Radix Inhibits Mast Cell Degranulation and Suppresses 2,4-Dinitrochlorobenzene-Induced Atopic Dermatitis-Like Skin Lesions.Mediators of inflammation · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Allergic diseases such as atopic dermatitis, rhinitis, asthma, and anaphylaxis are attractive research areas. Tyrosol (2-(4-hydroxyphenyl)ethanol) is a polyphenolic compound with diverse biological activities. In this study, we investigated whether tyrosol has anti-allergic inflammatory effects. Ovalbumin-induced active systemic anaphylaxis and immunoglobulin E-mediated passive cutaneous anaphylaxis models were used for the immediate-type allergic responses. Oral administration of tyrosol reduced the allergic symptoms of hypothermia and pigmentation in both animal models. Mast cells that secrete allergic mediators are key regulators on allergic inflammation. Tyrosol dose-dependently decreased mast cell degranulation and expression of inflammatory cytokines. Intracellular calcium levels and activation of inhibitor of κB kinase (IKK) regulate cytokine expression and degranulation. Tyrosol blocked calcium influx and phosphorylation of the IKK complex. To define the molecular target for tyrosol, various signaling proteins involved in mast cell activation such as Lyn, Syk, phosphoinositide 3-kinase (PI3K), and Akt were examined. Our results showed that PI3K could be a molecular target for tyrosol in mast cells. Taken together, these findings indicated that tyrosol has anti-allergic inflammatory effects by inhibiting the degranulation of mast cells and expression of inflammatory cytokines; these effects are mediated via PI3K. Therefore, we expect tyrosol become a potential therapeutic candidate for allergic inflammatory disorders.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.