ArticleScience (New York, N.Y.)2015
TISSUE REGENERATION. Inhibition of the prostaglandin-degrading enzyme 15-PGDH potentiates tissue regeneration.
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In one paragraph
Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 172 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
172citing papers in PubMed, 1 pooled it
16.0field-weighted citation impact, top 1% of its field
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
172 citing papers in PubMed, 1 synthesis or guideline pooled it, 284 citations in OpenAlex.
- Two cases of primary hypertrophic osteoarthropathy caused by HPGD variants: a case report and literature review.BMC pediatrics · 2025Pooled it
- Inhibition of neogenin fosters resolution of inflammation and tissue regeneration.The Journal of clinical investigation · 2018Trial
- AA in Rheumatoid Arthritis and Lupus.Reviews of physiology, biochemistry and pharmacology · 2027Review
- General View of Arachidonic Acid (AA) Metabolism.Reviews of physiology, biochemistry and pharmacology · 2027Review
- Network pharmacology, single-cell transcriptomics, machine learning and experimental validation identifying CHEK2 and HPGD as key therapeutic targets of berberine in diabetic nephropathy.Functional & integrative genomics · 2026Article
- Targeting prostaglandin catabolism via topical nanotherapy rescues vision in ischemic optic neuropathy.Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics · 2026Article
- Strengthening muscle for healthy ageing: innovative treatments for sarcopenia.Nature reviews. Drug discovery · 2026Review
- Inhibiting 15-PGDH restores redox homeostasis and confers neuroprotection in Parkinson's disease.Redox biology · 2026Article
- Engineered HMGB1 construct with tandem Box B domains promotes tissue regeneration without potential for inflammation.iScience · 2026Article
- Breaking the Barrier: Pro-inflammatory Stool from Infants with CHD Triggers Barrier Dysfunction within Intestinal Organoids.Research square · 2026Article
- Placental nicotinamide adenine dinucleotide modulates the timing of labor.Science (New York, N.Y.) · 2026Article
- 15-PGDH inhibition promotes muscle repair and strength recovery during GLP-1 receptor agonist-induced weight loss.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Article
- Molecular evolution of animal aging.The EMBO journal · 2026Review
- PGE2 regulates ferroptosis and osteogenesis of MC3T3-E1 cells via NOS2.Scientific reports · 2026Article
- Inhibition of 15-hydroxy prostaglandin dehydrogenase promotes cartilage regeneration.Science (New York, N.Y.) · 2026Article
- 15-PGDH Inhibition Overcomes Muscle Regenerative Deficit Seen With GLP1-Receptor Agonist-Induced Weight Loss.bioRxiv : the preprint server for biology · 2026Article
- Gut Microbiota Mediate the Metabolism of Colonic Prostaglandins.Research square · 2026Article
- Content of Fatty Acid and Eicosanoids in Muscle and Intestinal Tissue of C57BL/6 Mice Subjected to Long-Term Caloric Restriction.Nutrients · 2026Article
- The dual pathological roles and targeted therapy of PGEFrontiers in pharmacology · 2026Review
112 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
32 authors at 4 institutions in 1 country.
Yongyou ZhangDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Amar DesaiDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Sung Yeun YangDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Gastroenterology, Haeundae Paik Hospital, Inje University, Busan 612896, South Korea.
Ki Beom BaeDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Surgery, Busan Paik Hospital, and Paik Institute of Clinical Research and Ocular Neovascular Research Center, Inje University, Busan, South Korea.
Monika I AntczakDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Stephen P FinkDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Shruti TiwariDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Joseph E WillisCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Noelle S WilliamsDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Dawn M DawsonCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA.
David WaldCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Pathology, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Wei-Dong ChenDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Zhenghe WangCase Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Department of Genetics and Genome Sciences, Case Western Reserve University, Cleveland, OH 44106, USA.
Lakshmi KasturiDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Gretchen A LaruschDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Lucy HeDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Fabio CominelliDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Luca Di MartinoDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Zora DjuricDepartment of Family Medicine, University of Michigan, Ann Arbor MI 48109, USA.
Ginger L MilneDepartment of Pharmacology, Vanderbilt University, Nashville, TN 37232, USA.
Mark ChanceProteomics Center, Case Western Reserve University, Cleveland, OH 44106, USA.
Juan SanabriaDepartment of Surgery, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA.
Chris DealwisDepartment of Pharmacology, Case Western Reserve University, Cleveland, OH 44106, USA.
Debra MikkolaDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA.
Jacinth NaidooDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Shuguang WeiDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA.
Hsin-Hsiung TaiCollege of Pharmacy, University of Kentucky, Lexington, KY 40536, USA.
Stanton L GersonDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu.
Joseph M ReadyDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu.
Bruce PosnerDepartment of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu.
James K V WillsonSimmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu.
Sanford D MarkowitzDepartment of Medicine, Case Western Reserve University, Cleveland, OH 44106, USA. Case Comprehensive Cancer Center, Case Western Reserve University, Cleveland, OH 44106, USA. Case Medical Center, University Hospitals of Cleveland, Cleveland, OH 44106, USA. sxm10@cwru.edu james.willson@utsouthwestern.edu slg5@cwru.edu joseph.ready@utsouthwestern.edu bruce.posner@utsouthwestern.edu.
Case Western Reserve University · USThe University of Texas Southwestern Medical Center · USUniversity of Kentucky · USVanderbilt University · US
Funding
TUMOR METABOLISM PROGRAMP30CA043703 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARK R CHANCE · 1987 to 2026
$142.3MUT Southwestern Medical Center Simmons Comprehensive Cancer CenterP30CA142543 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI Sandi Leigh Pruitt · 2010 to 2026
$53.7MClinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0MStructure guided discovery of small molecule antagonists of Smac (DIABLO)/XIPAP01CA095471 · NCI · UT SOUTHWESTERN MEDICAL CENTER · PI MCKNIGHT, STEVEN L · 2002 to 2011
$34.1MTargeting 15-PGDH in Colon Cancer Prognosis, Prediction, Treatment and PreventionP50CA150964 · NCI · CASE WESTERN RESERVE UNIVERSITY · PI MARKOWITZ, SANFORD D. · 2011 to 2022
$24.6MRegional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3MThe Cleveland Digestive Diseases Research Core Center (DDRCC)P30DK097948 · NIDDK · CASE WESTERN RESERVE UNIVERSITY · PI Theresa Torres Pizarro · 2015 to 2026
$15.6MThe Cleveland Clinic Innovation AcceleratorU54HL119810 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI VINCE, D. GEOFFREY · 2013 to 2020
$14.4MTranslational Research in GI CancerP50CA130810 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BRENNER, DEAN E. · 2010 to 2016
$11.8MMECHANISMS OF EXPERIMENTAL CROHNS DISEASER01DK055812 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO · 1999 to 2019
$4.9MTranslational Research in Regenerative MedicineT32EB005583 · NIBIB · RUTGERS, THE STATE UNIV OF N.J. · PI LEE, KIBUM, PAREKKADAN, BIJU · 2006 to 2022
$4.7MCYTOKINES AND INFLAMMATORY BOWEL DISEASER01DK042191 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI COMINELLI, FABIO, PIZARRO, THERESA TORRES · 1995 to 2022
$4.7MHoward Hughes Medical InstituteNCATS NIH HHS UL1 TR000439NCI NIH HHS 1P01CA95471-09NCI NIH HHS 5P30 CA142543-03NCI NIH HHS P01 CA095471NCI NIH HHS P30 CA043703NCI NIH HHS P30 CA142543NCI NIH HHS P50 CA130810NCI NIH HHS P50 CA150964NCI NIH HHS R01 CA127590NCI NIH HHS R25 CA148052NCI NIH HHS R25CA148052NHLBI NIH HHS U54 HL119810NHLBI NIH HHS U54HL119810NIBIB NIH HHS T32 EB005583NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK097948NIDDK NIH HHS R01 DK042191NIDDK NIH HHS R01 DK055812
Abstract
Agents that promote tissue regeneration could be beneficial in a variety of clinical settings, such as stimulating recovery of the hematopoietic system after bone marrow transplantation. Prostaglandin PGE2, a lipid signaling molecule that supports expansion of several types of tissue stem cells, is a candidate therapeutic target for promoting tissue regeneration in vivo. Here, we show that inhibition of 15-hydroxyprostaglandin dehydrogenase (15-PGDH), a prostaglandin-degrading enzyme, potentiates tissue regeneration in multiple organs in mice. In a chemical screen, we identify a small-molecule inhibitor of 15-PGDH (SW033291) that increases prostaglandin PGE2 levels in bone marrow and other tissues. SW033291 accelerates hematopoietic recovery in mice receiving a bone marrow transplant. The same compound also promotes tissue regeneration in mouse models of colon and liver injury. Tissues from 15-PGDH knockout mice demonstrate similar increased regenerative capacity. Thus, 15-PGDH inhibition may be a valuable therapeutic strategy for tissue regeneration in diverse clinical contexts.
Indexed as
AnimalsBone Marrow TransplantationColitisDinoprostoneEnzyme InhibitorsHematopoiesisHydroxyprostaglandin DehydrogenasesLiver RegenerationMiceMice, KnockoutProstaglandinsPyridinesRegenerationThiophenes15-hydroxyprostaglandin dehydrogenaseDinoprostoneEnzyme InhibitorsHydroxyprostaglandin DehydrogenasesProstaglandinsPyridinesSW033291Thiophenes
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