Evidence map›Paper›PMID 26068849›Full record

ArticleScience (New York, N.Y.)2015

BRAIN NETWORKS. Correlated gene expression supports synchronous activity in brain networks.

Jonas Richiardi, Andre Altmann, Anna-Clare Milazzo, Catie Chang, M Mallar Chakravarty, Tobias Banaschewski, Gareth J Barker, Arun L W Bokde, Uli Bromberg, Christian Büchel and 24 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Science (New York, N.Y.), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 357 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
357citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

357 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
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  10. Diffusion MRI reveals amyloid plaque-associated cellular signatures through spatial transcriptomic integration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
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  16. Shared spatial and temporal principles govern connectome dynamics across timescales.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
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  18. Review
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297 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

34 authors.

Jonas RichiardiFunctional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. Laboratory of Neurology and Imaging of Cognition, Department of Neuroscience, University of Geneva, Geneva, Switzerland. jonas.richiardi@unige.ch greicius@stanford.edu.
Andre AltmannFunctional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Anna-Clare MilazzoThe War Related Illness and Injury Study Center, VA Palo Alto Health Care System, Palo Alto, CA, USA. Functional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA.
Catie ChangAdvanced MRI Section, Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
M Mallar ChakravartyCerebral Imaging Centre, Douglas Mental Health University Institute, Montreal, Canada. Departments of Psychiatry and Biomedical Engineering, McGill University, Montreal, Canada.
Tobias BanaschewskiDepartment of Child and Adolescent Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Gareth J BarkerInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Arun L W BokdeInstitute of Neuroscience, Trinity College Dublin, Dublin, Ireland.
Uli BrombergUniversitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
Christian BüchelUniversitaetsklinikum Hamburg Eppendorf, Hamburg, Germany.
Patricia ConrodInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Department of Psychiatry, Université de Montréal, Centre Hospitalier Universitaire (CHU) Ste Justine Hospital, Montréal, Canada.
Mira Fauth-BühlerDepartment of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Herta FlorDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Vincent FrouinNeurospin, Commissariat à l'Energie Atomique et aux Energies Alternatives, Paris, France.
Jürgen GallinatDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Hugh GaravanInstitute of Neuroscience, Trinity College Dublin, Dublin, Ireland. Departments of Psychiatry and Psychology, University of Vermont, Burlington, VT, USA.
Penny GowlandSchool of Physics and Astronomy, University of Nottingham, Nottingham, UK.
Andreas HeinzDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Hervé LemaîtreInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging and Psychiatry," University Paris Sud, Orsay, France. INSERM Unit 1000 at Maison de Solenn, Assistance Publique Hôpitaux de Paris (APHP), Cochin Hospital, University Paris Descartes, Sorbonne Paris Cité, Paris, France.
Karl F MannDepartment of Addictive Behaviour and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Jean-Luc MartinotInstitut National de la Santé et de la Recherche Médicale, INSERM Unit 1000 "Neuroimaging and Psychiatry," University Paris Sud, Orsay, France. INSERM Unit 1000 at Maison de Solenn, Assistance Publique Hôpitaux de Paris (APHP), Cochin Hospital, University Paris Descartes, Sorbonne Paris Cité, Paris, France.
Frauke NeesDepartment of Cognitive and Clinical Neuroscience, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Tomáš PausRotman Research Institute, University of Toronto, Toronto, Canada. School of Psychology, University of Nottingham, Nottingham, UK.
Zdenka PausovaThe Hospital for Sick Children, University of Toronto, Toronto, Canada.
Marcella RietschelDepartment of Genetic Epidemiology in Psychiatry, Central Institute of Mental Health, Medical Faculty Mannheim, Heidelberg University, Mannheim, Germany.
Trevor W RobbinsBehavioural and Clinical Neuroscience Institute and Department of Psychology, University of Cambridge, Cambridge, UK.
Michael N SmolkaDepartment of Psychiatry and Psychotherapy, and Neuroimaging Center, Technische Universität Dresden, Dresden, Germany.
Rainer SpanagelDepartment of Psychopharmacology, Central Institute of Mental Health, Faculty of Clinical Medicine Mannheim, Mannheim, Germany.
Andreas StröhleDepartment of Psychiatry and Psychotherapy, Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Gunter SchumannInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK. Medical Research Council (MRC) Social, Genetic and Developmental Psychiatry (SGDP) Centre, London, UK.
Mike HawrylyczAllen Institute for Brain Science, Seattle, WA, USA.
Jean-Baptiste PolineHelen Wills Neuroscience Institute, University of California Berkeley, Berkeley, CA, USA.
Michael D GreiciusFunctional Imaging in Neuropsychiatric Disorders Laboratory, Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA, USA. jonas.richiardi@unige.ch greicius@stanford.edu.
IMAGEN consortium

Funding

Training U54EB020403 · NIBIB · UNIVERSITY OF SOUTHERN CALIFORNIA · PI THOMPSON, PAUL M · 2014 to 2018
$10.1M
Development of Resting-State fMRI as a Biomarker for Alzheimers DiseaseR01NS073498 · NINDS · STANFORD UNIVERSITY · PI GREICIUS, MICHAEL D · 2010 to 2014
$2.2M
Axon, Testosterone and Mental Health during AdolescenceR01MH085772 · NIMH · BAYCREST CENTRE FOR GERIATRIC CARE · PI PAUS, TOMAS · 2010 to 2014
$1.5M
Department of HealthMedical Research Council 93558Medical Research Council G0901858NIBIB NIH HHS U54 EB020403NIMH NIH HHS R01 MH085772NIMH NIH HHS R01 MH085772-01A1NINDS NIH HHS R01 NS073498NINDS NIH HHS R01NS073498Wellcome Trust
6 · The paper itself

Abstract

During rest, brain activity is synchronized between different regions widely distributed throughout the brain, forming functional networks. However, the molecular mechanisms supporting functional connectivity remain undefined. We show that functional brain networks defined with resting-state functional magnetic resonance imaging can be recapitulated by using measures of correlated gene expression in a post mortem brain tissue data set. The set of 136 genes we identify is significantly enriched for ion channels. Polymorphisms in this set of genes significantly affect resting-state functional connectivity in a large sample of healthy adolescents. Expression levels of these genes are also significantly associated with axonal connectivity in the mouse. The results provide convergent, multimodal evidence that resting-state functional networks correlate with the orchestrated activity of dozens of genes linked to ion channel activity and synaptic function.

Indexed as

TranscriptomeAdolescentAdultAnimalsBrainFemaleGene ExpressionHumansIon ChannelsMagnetic Resonance ImagingMaleMiceNerve NetNeural PathwaysPolymorphism, GeneticRestIon Channels

Identifiers

PMID26068849
PMCPMC4829082

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.