Evidence map›Paper›PMID 26068794›Full record

ArticleCell death & disease2015

Aspirin delays mesothelioma growth by inhibiting HMGB1-mediated tumor progression.

H Yang, L Pellegrini, A Napolitano, C Giorgi, S Jube, A Preti, C J Jennings, F De Marchis, E G Flores, D Larson and 10 more

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cell death & disease, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 56 papers.

0numbers the graph read from it
0cells of the map it votes in
56citing papers in PubMed
5.6field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

56 citing papers in PubMed, 81 citations in OpenAlex.

  1. Trial
  2. Article
  3. Review
  4. Review
  5. Advances in the Basic Sciences in Thoracic Oncology in the Last 20 Years and Their Translational Impact.Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer · 2026
    Review
  6. Review
  7. Review
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Review
  15. HMGB1 released by mesothelial cells drives the development of asbestos-induced mesothelioma.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  16. Review
  17. BAP1 is a novel regulator of HIF-1α.Proceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 5 institutions in 2 countries.

H YangUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
L PellegriniUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
A Napolitano1] University of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA [2] Department of Molecular Biosciences and Bioengineering, University of Hawaii, Honolulu, HI 96813, USA.
C GiorgiDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara 44121, Italy.
S JubeUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
A PretiSan Raffaele University and Scientific Institute, Milan 20132, Italy.
C J JenningsUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
F De MarchisSan Raffaele University and Scientific Institute, Milan 20132, Italy.
E G FloresUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
D LarsonUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
I PaganoUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.ORCID 0000000262480113
M TanjiUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
A PowersUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
S KanodiaSamuel Oschin Comprehensive Cancer Institute and Department of Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA 90048, USA.
G GaudinoUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
S PastorinoUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
H I PassDepartment of Cardiothoracic Surgery, New York Langone Medical Center, New York, NY 10016, USA.
P PintonDepartment of Morphology, Surgery and Experimental Medicine, University of Ferrara, Ferrara 44121, Italy.
M E BianchiSan Raffaele University and Scientific Institute, Milan 20132, Italy.
M CarboneUniversity of Hawaii Cancer Center, University of Hawaii, Honolulu, HI 96813, USA.
University of Hawaiʻi at Mānoa · USSan Raffaele University of Rome · ITUniversity of Ferrara · ITCedars-Sinai Medical Center · USNYU Langone Health · US

Funding

University of Hawaii Cancer Center CCSGP30CA071789 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI Xin Chen · 1996 to 2026
$56.2M
PATHOLOGY, VIROLOGY, AND ANIMAL COREP01CA114047 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI TESTA, JOSEPH R. · 2006 to 2010
$8.0M
The Role of HMGB1 in the Pathogenesis of MesotheliomaR01CA160715 · NCI · UNIVERSITY OF HAWAII AT MANOA · PI YANG, HAINING · 2011 to 2015
$1.5M
NCI NIH HHS P01 CA114047NCI NIH HHS P30 CA071789NCI NIH HHS R01 CA160715
6 · The paper itself

Abstract

High-mobility group box 1 (HMGB1) is an inflammatory molecule that has a critical role in the initiation and progression of malignant mesothelioma (MM). Aspirin (acetylsalicylic acid, ASA) is the most widely used nonsteroidal anti-inflammatory drug that reduces the incidence, metastatic potential and mortality of many inflammation-induced cancers. We hypothesized that ASA may exert anticancer properties in MM by abrogating the carcinogenic effects of HMGB1. Using HMGB1-secreting and -non-secreting human MM cell lines, we determined whether aspirin inhibited the hallmarks of HMGB1-induced MM cell growth in vitro and in vivo. Our data demonstrated that ASA and its metabolite, salicylic acid (SA), inhibit motility, migration, invasion and anchorage-independent colony formation of MM cells via a novel HMGB1-mediated mechanism. ASA/SA, at serum concentrations comparable to those achieved in humans taking therapeutic doses of aspirin, and BoxA, a specific inhibitor of HMGB1, markedly reduced MM growth in xenograft mice and significantly improved survival of treated animals. The effects of ASA and BoxA were cyclooxygenase-2 independent and were not additive, consistent with both acting via inhibition of HMGB1 activity. Our findings provide a rationale for the well documented, yet poorly understood antitumorigenic activity of aspirin, which we show proceeds via HMGB1 inhibition. Moreover, the use of BoxA appears to allow a more efficient HMGB1 targeting while eluding the known gastrointestinal side effects of ASA. Our findings are directly relevant to MM. Given the emerging importance of HMGB1 and its tumor-promoting functions in many cancer types, and of aspirin in cancer prevention and therapy, our investigation is poised to provide broadly applicable information.

Indexed as

3T3 CellsAnimalsAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsAspirinCell Line, TumorCell MovementCell ProliferationCyclooxygenase 2Epithelial-Mesenchymal TransitionFemaleHMGB1 ProteinLung NeoplasmsMesotheliomaMesothelioma, MalignantMiceAnti-Inflammatory Agents, Non-SteroidalAntineoplastic AgentsAspirinCyclooxygenase 2HMGB1 ProteinHMGB1 protein, mousePtgs2 protein, mouseSalicylic Acid

Identifiers

PMID26068794
PMCPMC4669834
OpenAlexW1532588118

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.