ArticleJournal of visualized experiments : JoVE2015
A Piglet Model of Neonatal Hypoxic-Ischemic Encephalopathy.
Article in Journal of visualized experiments : JoVE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 37 citations in OpenAlex.
- Modeling cerebral palsy in animals.Developmental medicine and child neurology · 2026Review
- Improved Paediatric Procedural Competence and Knowledge After Training Using a Newborn Piglet Model.Acta paediatrica (Oslo, Norway : 1992) · 2026Article
- Prominent astrocytic GLAST pathology occurs in newborn human and piglet hypoxic-ischemic encephalopathy: modeling relationships among laminar neuropathology, seizures, and therapeutic hypothermia.Frontiers in cellular neuroscience · 2026Article
- Early changes in cerebral metabolism after perinatal hypoxia-ischemia: a study in normothermic and hypothermic piglets.Frontiers in pediatrics · 2023Article
- Transcranial Doppler Ultrasonography detection on cerebrovascular flow for evaluating neonatal hypoxic-ischemic encephalopathy modeling.Frontiers in neuroscience · 2023Article
- Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps.Frontiers in pediatrics · 2023Review
- No neuroprotective effect of therapeutic hypothermia following lipopolysaccharide-sensitized hypoxia-ischemia: a newborn piglet study.Frontiers in pediatrics · 2023Article
- Technical feasibility of multimodal imaging in neonatal hypoxic-ischemic encephalopathy from an ovine model to a human case series.Frontiers in pediatrics · 2023Article
- No Differences in Cerebral Immunohistochemical Markers following Remote Ischemic Postconditioning in Newborn Piglets with Hypoxia-Ischemia.Neuropediatrics · 2022Article
- Hypothermia and heart rate variability in a healthy newborn piglet model.Scientific reports · 2022Article
- Remote ischemic postconditioning increased cerebral blood flow and oxygenation assessed by magnetic resonance imaging in newborn piglets after hypoxia-ischemia.Frontiers in pediatrics · 2022Article
- Neurofilament Light Chain serum levels after Hypoxia-Ischemia in a newborn piglet model.Frontiers in pediatrics · 2022Article
- Short-term outcomes of remote ischemic postconditioning 1 h after perinatal hypoxia-ischemia in term piglets.Pediatric research · 2021Article
- Characterization of oxidative stress in animal model of neonatal hypoxia.Acta cirurgica brasileira · 2021Article
- Disrupted brain connectivity in children treated with therapeutic hypothermia for neonatal encephalopathy.NeuroImage. Clinical · 2021Article
- How to Improve the Antioxidant Defense in Asphyxiated Newborns-Lessons from Animal Models.Antioxidants (Basel, Switzerland) · 2020Review
- No Added Neuroprotective Effect of Remote Ischemic Postconditioning and Therapeutic Hypothermia After Mild Hypoxia-Ischemia in a Piglet Model.Frontiers in pediatrics · 2020Article
- Consequence of insertion trauma - effect on early measurements when using intracerebral devices.Scientific reports · 2019Article
- Ontogeny of white matter, toll-like receptor expression, and motor skills in the neonatal ferret.International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience · 2018Article
- Expression Changes in Lactate and Glucose Metabolism and Associated Transporters in Basal Ganglia following Hypoxic-Ischemic Reperfusion Injury in Piglets.AJNR. American journal of neuroradiology · 2018Article
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Birth asphyxia, which causes hypoxic-ischemic encephalopathy (HIE), accounts for 0.66 million deaths worldwide each year, about a quarter of the world's 2.9 million neonatal deaths. Animal models of HIE have contributed to the understanding of the pathophysiology in HIE, and have highlighted the dynamic process that occur in brain injury due to perinatal asphyxia. Thus, animal studies have suggested a time-window for post-insult treatment strategies. Hypothermia has been tested as a treatment for HIE in pdiglet models and subsequently proven effective in clinical trials. Variations of the model have been applied in the study of adjunctive neuroprotective methods and piglet studies of xenon and melatonin have led to clinical phase I and II trials(1,2). The piglet HIE model is further used for neonatal resuscitation- and hemodynamic studies as well as in investigations of cerebral hypoxia on a cellular level. However, it is a technically challenging model and variations in the protocol may result in either too mild or too severe brain injury. In this article, we demonstrate the technical procedures necessary for establishing a stable piglet model of neonatal HIE. First, the newborn piglet (< 24 hr old, median weight 1500 g) is anesthetized, intubated, and monitored in a setup comparable to that found in a neonatal intensive care unit. Global hypoxia-ischemia is induced by lowering the inspiratory oxygen fraction to achieve global hypoxia, ischemia through hypotension and a flat trace amplitude integrated EEG (aEEG) indicative of cerebral hypoxia. Survival is promoted by adjusting oxygenation according to the aEEG response and blood pressure. Brain injury is quantified by histopathology and magnetic resonance imaging after 72 hr.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.