Evidence map›Paper›PMID 26068541›Full record

ArticleDiabetes2015

Müller Glia Are a Major Cellular Source of Survival Signals for Retinal Neurons in Diabetes.

Shuhua Fu, Shuqian Dong, Meili Zhu, David M Sherry, Changyun Wang, Zhipeng You, Jody J Haigh, Yun-Zheng Le

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Diabetes, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 70 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
70citing papers in PubMed, 1 pooled it
3.9field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

70 citing papers in PubMed, 1 synthesis or guideline pooled it, 106 citations in OpenAlex.

  1. Pooled it
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  19. The Role of Müller Cells in Diabetic Macular Edema.Investigative ophthalmology & visual science · 2023
    Review
  20. Review

10 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 4 countries.

Shuhua FuDepartment of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, China Section of Endocrinology and Diabetes, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Shuqian DongSection of Endocrinology and Diabetes, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK Department of Ophthalmology, Xiangya Hospital, Central South University, Changsha, China.
Meili ZhuSection of Endocrinology and Diabetes, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK.
David M SherryDepartment of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK.
Changyun WangDepartment of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Zhipeng YouDepartment of Ophthalmology, The Second Affiliated Hospital of Nanchang University, Nanchang, China.
Jody J HaighVascular Cell Biology Unit, VIB Inflammation Research Center, Ghent University, Ghent, Belgium Department for Biomedical Molecular Biology, Ghent University, Ghent, Belgium Mammalian Functional Genetics Laboratory, Division of Blood Cancers, Australian Centre for Blood Diseases, Monash University and Alfred Health Centre, Melbourne, Victoria, Australia Department of Clinical Haematology, Monash University and Alfred Health Centre, Melbourne, Victoria, Australia.
Yun-Zheng LeSection of Endocrinology and Diabetes, Department of Medicine, The University of Oklahoma Health Sciences Center, Oklahoma City, OK Department of Cell Biology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK Department of Ophthalmology, The University of Oklahoma Health Sciences Center, Oklahoma City, OK Harold Hamm Diabetes Center, The University of Oklahoma Health Sciences Center, Oklahoma City, OK yun-le@ouhsc.edu.
University of Oklahoma Health Sciences Center · USNanchang University · CNMonash University · AU

Funding

Project 5 VEGF Signaling in PhotoreceptorsP20GM104934 · NIGMS · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LE, YUN ZHENG · 2012 to 2016
$10.8M
P30-CENTER CORE GRANT FOR VISION RESEARCHP30EY021725 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI Michelle C Callegan · 2011 to 2026
$10.5M
Study of the RPE barrierR01EY020900 · NEI · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI LE, YUN ZHENG · 2010 to 2013
$1.4M
NEI NIH HHS EY020900NEI NIH HHS EY021725NEI NIH HHS P30 EY021725NEI NIH HHS R01 EY020900NIGMS NIH HHS GM104934NIGMS NIH HHS P20 GM104934
6 · The paper itself

Abstract

To dissect the role of vascular endothelial growth factor receptor-2 (VEGFR2) in Müller cells and its effect on neuroprotection in diabetic retinopathy (DR), we disrupted VEGFR2 in mouse Müller glia and determined its effect on Müller cell survival, neuronal integrity, and trophic factor production in diabetic retinas. Diabetes was induced with streptozotocin. Retinal function was measured with electroretinography. Müller cell and neuronal densities were assessed with morphometric and immunohistochemical analyses. Loss of VEGFR2 caused a gradual reduction in Müller glial density, which reached to a significant level 10 months after the onset of diabetes. This observation was accompanied by an age-dependent decrease of scotopic and photopic electroretinography amplitudes and accelerated loss of rod and cone photoreceptors, ganglion cell layer cells, and inner nuclear layer neurons and by a significant reduction of retinal glial cell line-derived neurotrophic factor and brain-derived neurotrophic factor. Our results suggest that VEGFR2-mediated Müller cell survival is required for the viability of retinal neurons in diabetes. The genetically altered mice established in this study can be used as a diabetic animal model of nontoxin-induced Müller cell ablation, which will be useful for exploring the cellular mechanisms of neuronal alteration in DR.

Indexed as

AnimalsCells, CulturedDiabetic RetinopathyElectroretinographyEpendymoglial CellsGene Expression RegulationMiceMice, KnockoutRetinal NeuronsSignal TransductionVascular Endothelial Growth Factor Receptor-2Vascular Endothelial Growth Factor Receptor-2

Identifiers

PMID26068541
PMCPMC4587642
OpenAlexW2175933822

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.