ArticleArchives of microbiology2015
Inter- and intra-individual variations in seasonal and daily stabilities of the human gut microbiota in Japanese.
Article in Archives of microbiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 102 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
102 citing papers in PubMed, 2 syntheses or guidelines pooled it, 150 citations in OpenAlex.
- Colonization Ability and Impact on Human Gut Microbiota of Foodborne Microbes From Traditional or Probiotic-Added Fermented Foods: A Systematic Review.Frontiers in nutrition · 2021Pooled it
- Climate factors and gestational diabetes mellitus risk - a systematic review.Environmental health : a global access science source · 2020Pooled it
- Rifaximin Improves Cognitive Performance and Reduces Cirrhosis-Related Adverse Events in Covert Hepatic Encephalopathy: A Randomized Controlled Trial.Alimentary pharmacology & therapeutics · 2026Trial
- Cholestasis-reducing effects of bezafibrate on survivors of biliary atresia with native livers: A prospective phase II trial.Hepatology communications · 2026Trial
- Trial
- Trial
- Effects of short-term endurance exercise on gut microbiota in elderly men.Physiological reports · 2018Trial
- The Effect of White Rice and White Bread as Staple Foods on Gut Microbiota and Host Metabolism.Nutrients · 2018Trial
- Effects of Seasonality and Air Pollution on the Nasal Microbiota in Healthy Italian Adults.Hygiene and environmental health advances · 2026Article
- Association of gut microbiota with central blood pressure and pulse pressure amplification in community-dwelling Japanese adults: the Wakayama study.Journal of human hypertension · 2026Article
- Effects of processed low-protein brown rice on patients with chronic kidney disease.Clinical and experimental nephrology · 2026Article
- Article
- Towards a Standard Protocol for Fecal Microbiota Transplantation in Irritable Bowel Syndrome.Journal of neurogastroenterology and motility · 2026Review
- Association of Human Gut Microbiota with Alzheimer's Disease Pathogenesis: An Exploratory Clinical Study.Brain sciences · 2026Article
- Involvement of Megasphaera in the oral microbiome and dyslipidemia onset: evidence from a community-based study in Japan.Folia microbiologica · 2026Article
- Stability of equol production capability is associated with the diversity of the gut microbiota of the host: a prospective cohort study.BMC microbiology · 2026Article
- Meeting WHO physical activity standards may promote greater gut microbiota diversity and preservation of Ruminococcus in community-dwelling older women.Environmental health and preventive medicine · 2026Article
- Increased intestinalGut microbes reports · 2026Article
- Trends and seasonal variation in the incidence and prevalence of irritable bowel syndrome in Korea: a multicenter OMOP CDM study.Frontiers in public health · 2026Article
- Characterization of gut microbiota dysbiosis in breast cancer patients.Breast cancer (Tokyo, Japan) · 2026Article
42 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Relationships between human gut microbiota, dietary habits, and health/diseases are the subject of epidemiological and clinical studies. However, the temporal stability and variability of the bacterial community in fecal samples remain unclear. In this study, middle-aged Japanese male and female volunteers (n = 5 each) without disease were recruited from the Sakura Diet Study. Fecal samples and lifestyle information were collected in every quarter and at each defecation for 7 continuous days. Next-generation sequencing of 16S rDNA and hierarchical clustering showed no time trend and intra-individual differences in both fecal sample sets. Significant inter-individual variations in seasonal and daily fecal sample sets were detected for 24 and 23 out of 39 selected dominant genera (>0.1% of the total human gut microbiota; occupation rate >85%), respectively. Intra- to inter-individual variance ratios in 26 and 35 genera were significantly <1.0 for seasonal and daily stabilities. Seasonal variation in fermented milk consumption might be associated with Bifidobacterium composition, but not with Lactobacillus. For most of the dominant genera in the human gut microbiota, inter-individual variations were significantly larger than intra-individual variations. Further studies are warranted to determine the contributions of human gut microbiota to nutritional metabolism, health promotion, and prevention/development of diseases.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.