Evidence map›Paper›PMID 26068507›Full record

ArticleBMJ open2015

Cost-effectiveness of a repeat HIV test in pregnancy in India.

Smita Joshi, Vinay Kulkarni, Raman Gangakhedkar, Uma Mahajan, Sushma Sharma, Devendra Shirole, Nomita Chandhiok

Abstract read
In one paragraph

Article in BMJ open, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Article
  4. Article
  5. Article
  6. Article
  7. Review
  8. Article
  9. Article
  10. The social stigma of HIV-AIDS: society's role.HIV/AIDS (Auckland, N.Z.) · 2017
    Article
  11. Cost-Effectiveness of Universal Repeat Human Immunodeficiency Virus Screening in Pregnancy: A Cross-Sectional Study from Western India.Indian journal of community medicine : official publication of Indian Association of Preventive & Social Medicine
    Article
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Smita JoshiDepartment of Preventive Oncology, Hirabai Cowasji Jehangir Medical Research Institute (HCJMRI), Pune, Maharashtra, India.
Vinay KulkarniPrayas Health Group, Amrita Clinic, Pune, Maharashtra, India.
Raman GangakhedkarNational AIDS Research Institute, Pune, Maharashtra, India.
Uma MahajanDepartment of Preventive Oncology, Hirabai Cowasji Jehangir Medical Research Institute (HCJMRI), Pune, Maharashtra, India.
Sushma SharmaMIMER Hospital, Pune, Maharashtra, India.
Devendra ShiroleKamla Nehru Hospital, Pune Municipal Corporation, Pune, Maharashtra, India.
Nomita ChandhiokIndian Council of Medical Research, New Delhi, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo evaluate cost-effectiveness of second HIV test in pregnancy.

backgroundCurrent strategy of single HIV test during pregnancy in India can miss new HIV infections acquired after the first test or those HIV infections that were missed in the first test due to a false-negative HIV test.

methodsBetween August 2011 and April 2013, 9097 pregnant HIV uninfected women were offered a second HIV test near term (34 weeks or beyond) or within 4 weeks of postpartum period. A decision analysis model was used to evaluate cost-effectiveness of a second HIV test in pregnant women near term. PRIMARY AND SECONDARY OUTCOME: Our key outcome measures include programme cost with addition of second HIV test in pregnant women and quality-adjusted life years (QALYs) gained.

resultsWe detected 4 new HIV infections in the second test. Thus HIV incidence among pregnant women was 0.12 (95% 0.032 to 0.297) per 100 person women years (PWY). Current strategy of a single HIV test is 8.2 times costlier for less QALYs gained as compared to proposed repeat HIV testing of pregnant women who test negative during the first test.

conclusionsOur results warrant consideration at the national level for including a second HIV test of all pregnant women in the national programme. However prior to allocation of resources for a second HIV test in pregnancy, appropriate strategies will have to be planned for improving compliance for prevention of mother-to-child transmission of HIV and reducing loss-to-follow-up of those women detected with HIV. TRIAL REGISTRATION NUMBER: CTRI/2013/12/004183.

Indexed as

Cost-Benefit AnalysisHIVMass ScreeningPrenatal CareQuality-Adjusted Life YearsAdultDecision Support TechniquesFemaleHIV InfectionsHumansIncidenceIndiaPregnancyPregnancy Complications, InfectiousYoung AdultEPIDEMIOLOGY

Identifiers

PMID26068507
PMCPMC4466614

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.