ArticlePloS one2015
Analysis of Early Postoperative Pain in the First and Second Knee in Staged Bilateral Total Knee Arthroplasty: A Retrospective Controlled Study.
Article in PloS one, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03792828 (Pre-emptive Effect of Duloxetine in the Second Knee in Staged Total Knee Arthroplasty), which is not on this map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pre-emptive Effect of Duloxetine in the Second Knee in Staged Total Knee Arthroplasty: A Randomized Controlled Study
Who cites it
9 citing papers in PubMed, 23 citations in OpenAlex.
- Prevalence and Nomogram-Based Prediction Model of Neuropathic Pain After Knee Arthroplasty.Journal of pain research · 2026Article
- Second-Stage Knee Pain is Not Increased After Staged Bilateral Total Knee Arthroplasty: A Retrospective Linear Mixed-Effects Analysis of 72-Hour Postoperative Pain.Orthopedic research and reviews · 2026Article
- Postoperative Pain and Opiate Requirement is Increased Following Second-Side Surgery Among Patients Undergoing Staged Total Knee Arthroplasty.Arthroplasty today · 2025Article
- High Pain Self-Efficacy Reduces the Use of Analgesics in the Early Postoperative Period After Total Knee Arthroplasty: A Retrospective Cohort Study.Journal of pain research · 2025Article
- Establishment and Validation of Risk Prediction Models for Postoperative Pain After Endoscopic Submucosal Dissection: A Retrospective Clinical Study.Journal of multidisciplinary healthcare · 2024Article
- Patient-reported dissatisfaction following second side in staged bilateral total knee arthroplasty: A systematic review.World journal of orthopedics · 2022Article
- Comparison of Efficacy of Adductor Canal Block, Local Infiltration Analgesia and Both Combined in Postoperative Pain Management After Total Knee Arthroplasty: A Randomized Controlled Trial.Indian journal of orthopaedics · 2021Article
- Are patient-reported outcomes the same following second-side surgery in primary hip and knee arthroplasty?Bone & joint open · 2021Article
- Comparative Outcomes Between the First and Second Operated Shoulders in Bilateral Shoulder Arthroplasty.Journal of the American Academy of Orthopaedic Surgeons. Global research & reviews · 2018Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveA retrospective analysis of early postoperative pain in the first and second knee in staged bilateral total knee arthroplasty (TKA) to provide a clinical evidence for the change of analgesic strategy.
methodsFrom January 2009 to January 2013, 87 cases which meet the inclusion criterion were retrospectively reviewed. In stage TKA, the postoperative pain in the first and second knee at 24 h, 48 h, 72 h after operation were compared using the visual analogue scale (VAS) score in the rest and maximum knee flexion position. The difference in pain scores (ΔVAS) was also compared between the second and first knee at different time intervals (less than 6 months, 6-12 months, more than 12 months).
resultsThe VAS scores in the second knee were significantly higher than those in the first knee at 24 h, 48 h after surgery, but with no difference at 72 h. The ΔVAS in the group of less than 6 months was significantly higher than of those more than 6 months, and there was no difference in ΔVAS between group of 6-12 months and group of more than 12 months.
conclusionsPatient receiving staged bilateral TKA experiences greater postoperative pain within 48 h after operation in the second knee than in the first knee, which can provide a clinical evidence to enhance the analgesic strategy in the second operation of the staged bilateral TKA. And for the management of postoperative pain in staged bilateral TKA, it's better to recommend that the interval between two operations should be more than 6 months, which may reduce the postoperative pain in the second knee, improve patient satisfaction, and speed up patient's rehabilitation process.
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