Evidence map›Paper›PMID 26068298›Full record

Trial reportOsteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA2015

Comparative performance of current definitions of sarcopenia against the prospective incidence of falls among community-dwelling seniors age 65 and older.

H A Bischoff-Ferrari, J E Orav, J A Kanis, R Rizzoli, M Schlögl, H B Staehelin, W C Willett, B Dawson-Hughes

2 registry-linked trialsAbstract readComparative StudyRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 180 papers, 18 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
180citing papers in PubMed, 18 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07269600 active not recruitingnot on this mapstarted 2025, after this paper: background citation

The Effects of Sarcopenia on Cervical Proprioception, Kinesiophobia and Pressure Pain Threshold in Geriatric Nursing Home Residents

Typeobservational_patient_registrySponsorAtılım UniversityRan2025 to 2026Enrolled31ConditionsSarcopenia in Elderly
NCT07356440 naactive not recruitingnot on this mapstarted 2025, after this paper: background citation

Effect of Consumption of Vegetable Protein-enriched Biscuits and Vitamin D Supplementation on the Progression of Sarcopenia in Elderly Subjects

TypeinterventionalSponsorUniversity of UdineRan2025 to 2026Enrolled74ConditionsSarcopenia in Elderly, Sarcopenia, Nutritional Intervention, Microbiome AnalysisArmsVitamin D3 supplement, Protein-enriched biscuits, Control biscuit, Placebo oil
3 · Its place in the literature

Who cites it

180 citing papers in PubMed, 18 syntheses or guidelines pooled it.

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  10. Prevalence of Sarcopenia in Africa: A Systematic Review.Clinical interventions in aging · 2023
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  14. Sarcopenia Definitions as Predictors of Fracture Risk Independent of FRAXJournal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2021
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120 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

H A Bischoff-FerrariDepartment of Geriatrics and Aging Research, University Hospital Zurich, Raemistrasse 101, 8091, Zurich, Switzerland. Heike.Bischoff@usz.ch.
J E OravDepartment of Biostatistics, Harvard School of Public Health, Boston, MA, USA.
J A KanisCentre for Metabolic Bone Diseases, University of Sheffield, Sheffield, UK.
R RizzoliService of Bone Diseases, Geneva University Hospitals and Faculty of Medicine, Geneva, Switzerland.
M SchlöglDepartment of Geriatrics and Aging Research, University Hospital Zurich, Raemistrasse 101, 8091, Zurich, Switzerland.
H B StaehelinDepartment of Geriatrics, University of Basel, Basel, Switzerland.
W C WillettDepartment of Nutrition, Harvard School of Public Health, Boston, MA, USA.
B Dawson-HughesUSDA Human Nutrition Research Center on Aging, Tufts University, Boston, MA, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

unlabelledIn this study, we compare the extent to which seven available definitions of sarcopenia and two related definitions predict the rate of falling. Our results suggest that the definitions of Baumgartner and Cruz-Jentoft best predict the rate of falls among sarcopenic versus non-sarcopenic community-dwelling seniors.

introductionThe purpose of the study is to compare the extent to which seven available definitions of sarcopenia and two related definitions predict the prospective rate of falling.

methodsWe studied a cohort of 445 seniors (mean age 71 years, 45 % men) living in the community who were followed with a detailed fall assessment for 3 years. For comparing the rate of falls in sarcopenic versus non-sarcopenic individuals, we used multivariate Poisson regression analyses adjusting for gender and treatment (original intervention tested vitamin D plus calcium against placebo). Of the seven available definitions, three were based on low lean mass alone (Baumgartner, Delmonico 1 and 2) and four required both low muscle mass and decreased performance in a functional test (Fielding, Cruz-Jentoft, Morley, Muscaritoli). The two related definitions were based on low lean mass alone (Studenski 1) and low lean mass contributing to weakness (Studenski 2).

resultsAmong 445 participants, 231 fell, sustaining 514 falls over the 3-year follow-up. The prospective rate of falls in sarcopenic versus non-sarcopenic individuals was best predicted by the Baumgartner definition based on low lean mass alone (RR = 1.54; 95 % CI 1.09-2.18) with 11 % prevalence of sarcopenia and the Cruz-Jentoft definition based on low lean mass plus decreased functional performance (RR = 1.82; 95 % CI 1.24-2.69) with 7.1 % prevalence of sarcopenia. Consistently, fall rate was non-significantly higher in sarcopenic versus non-sarcopenic individuals based on the definitions of Delmonico 1, Fielding, and Morley.

conclusionAmong the definitions investigated, the Baumgartner definition and the Cruz-Jentoft definition had the highest validity for predicting the rate of falls.

Indexed as

Absorptiometry, PhotonAccidental FallsAgedAnthropometryCalciumDouble-Blind MethodDrug Therapy, CombinationFemaleGaitHand StrengthHumansIncidenceMalePrevalenceProspective StudiesResidence CharacteristicsCalciumVitamin DCommunity-dwelling seniorsComparative performanceFallsPrevalenceSarcopenia

Identifiers

PMID26068298

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.