ArticleScientific reports2015
Obesity-induced adipokine imbalance impairs mouse pulmonary vascular endothelial function and primes the lung for injury.
Article in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 51 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
51 citing papers in PubMed, 72 citations in OpenAlex.
- Impact of obesity on outcomes of patients with acute respiratory distress syndrome: a retrospective analysis of a large clinical database.Medizinische Klinik, Intensivmedizin und Notfallmedizin · 2024Article
- Inhibition of angiogenesis and regenerative lung growth inFrontiers in cardiovascular medicine · 2024Article
- Modulation of Dietary Fatty Acids in an Open-Label Study Improves Psoriasis and Dampens the Inflammatory Activation Status.Nutrients · 2023Article
- Mechanisms contributing to adverse outcomes of COVID-19 in obesity.Molecular and cellular biochemistry · 2022Review
- Exosomes from Human Placenta Choriodecidual Membrane-Derived Mesenchymal Stem Cells Mitigate Endoplasmic Reticulum Stress, Inflammation, and Lung Injury in Lipopolysaccharide-Treated Obese Mice.Antioxidants (Basel, Switzerland) · 2022Article
- Different Course of SARS-CoV-2 Infection in Two Adolescents With Other Immunosuppressive Factors.Cureus · 2022Article
- Overexpression of S100A9 in obesity impairs macrophage differentiation via TLR4-NFkB-signaling worsening inflammation and wound healing.Theranostics · 2022Article
- Delta-like ligand 4 level in colorectal cancer is associated with tumor aggressiveness and clinical outcome.Cancer biomarkers : section A of Disease markers · 2022Article
- High-fat Western diet consumption exacerbates silica-induced pulmonary inflammation and fibrosis.Toxicology reports · 2022Article
- Mediators of Obesity Do Not Influence SARS-CoV-2 Infection or Activation of Primary Human Lung Microvascular Endothelial CellsFrontiers in immunology · 2022Article
- Storage conditions of high-fat diets affect pulmonary inflammation.Physiological reports · 2021Article
- Effects of propofol and its formulation components on macrophages and neutrophils in obese and lean animals.Pharmacology research & perspectives · 2021Article
- The Role of Obesity in the Immunopathogenesis of COVID-19 Respiratory Disease and Critical Illness.American journal of respiratory cell and molecular biology · 2021Review
- Neutrophil oxidative stress mediates obesity-associated vascular dysfunction and metastatic transmigration.Nature cancer · 2021Article
- Hermansky-Pudlak syndrome-2 alters mitochondrial homeostasis in the alveolar epithelium of the lung.Respiratory research · 2021Article
- Retraction: Obesity-induced Endoplasmic Reticulum Stress Causes Lung Endothelial Dysfunction and Promotes Acute Lung Injury.American journal of respiratory cell and molecular biology · 2020Article
- Relapse of chronic obstructive pulmonary disease and myocardial infarction: what is the connection?European heart journal supplements : journal of the European Society of Cardiology · 2020Article
- Should patients with obesity be more afraid of COVID-19?Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Review
- Adiponectin Protects Obese Rats from Aggravated Acute Lung Injury via Suppression of Endoplasmic Reticulum Stress.Diabetes, metabolic syndrome and obesity : targets and therapy · 2020Article
- Adipose tissue quantification and primary graft dysfunction after lung transplantation: The Lung Transplant Body Composition study.The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation · 2019Article
Corrections and comments
- Expression of concern · 2021-09-15Concerns/Issues about Image ·
- Retraction · 2022-02-03Concerns/Issues about Data · Duplication of/in Image · Unreliable Results and/or Conclusions ·
- Retracted
Authors and funding
11 authors at 4 institutions in 2 countries.
Funding
Abstract
Obesity is a risk factor for the development of acute respiratory distress syndrome (ARDS) but mechanisms mediating this association are unknown. While obesity is known to impair systemic blood vessel function, and predisposes to systemic vascular diseases, its effects on the pulmonary circulation are largely unknown. We hypothesized that the chronic low grade inflammation of obesity impairs pulmonary vascular homeostasis and primes the lung for acute injury. The lung endothelium from obese mice expressed higher levels of leukocyte adhesion markers and lower levels of cell-cell junctional proteins when compared to lean mice. We tested whether systemic factors are responsible for these alterations in the pulmonary endothelium; treatment of primary lung endothelial cells with obese serum enhanced the expression of adhesion proteins and reduced the expression of endothelial junctional proteins when compared to lean serum. Alterations in pulmonary endothelial cells observed in obese mice were associated with enhanced susceptibility to LPS-induced lung injury. Restoring serum adiponectin levels reversed the effects of obesity on the lung endothelium and attenuated susceptibility to acute injury. Our work indicates that obesity impairs pulmonary vascular homeostasis and enhances susceptibility to acute injury and provides mechanistic insight into the increased prevalence of ARDS in obese humans.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.