ArticleAnesthesiology2015
Isoflurane Ameliorates Acute Lung Injury by Preserving Epithelial Tight Junction Integrity.
Article in Anesthesiology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 104 citations in OpenAlex.
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- Effect of Targeted Probiotics on Anesthesia-Induced Sleep Disturbances via Modulating the Gut Microbiome and Metabolites.Food science & nutrition · 2026Article
- Mitochondrial transplantation attenuates alveolar epithelial cell dysfunction and reduces disruption of tight junction proteins to alleviate lung ischaemia-reperfusion injury.Journal of translational medicine · 2025Article
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- Anesthetic choice impacts mortality and bacterial clearance in a murine experimental pneumonia model.BMC infectious diseases · 2025Article
- Ameliorating lipopolysaccharide induced acute lung injury with Lianhua Qingke: focus on pulmonary endothelial barrier protection.Journal of thoracic disease · 2024Article
- Inhaled volatile anesthetics in the intensive care unit.World journal of critical care medicine · 2024Review
- Quercetin alleviates lipopolysaccharide‑induced acute lung injury by inhibiting ferroptosis via the Sirt1/Nrf2/Gpx4 pathway.International journal of molecular medicine · 2023Article
- Effects of sevoflurane on lung epithelial permeability in experimental models of acute respiratory distress syndrome.Journal of translational medicine · 2023Article
- Strain-dependent lung transcriptomic differences in cigarette smoke and LPS models of lung injury in mice.Physiological genomics · 2023Article
- Sevoflurane sedation in COVID-19 acute respiratory distress syndrome: an observational study with a propensity score matching model.Frontiers in medicine · 2023Article
- Isoflurane vs. propofol for sedation in invasively ventilated patients with acute hypoxemic respiratory failure: an a priori hypothesis substudy of a randomized controlled trial.Annals of intensive care · 2022Article
- Mild Traumatic Brain Injury and Subsequent Acute Pulmonary Inflammatory Response.Journal of Korean Neurosurgical Society · 2022Article
- Ulinastatin alleviates pulmonary edema by reducing pulmonary permeability and stimulating alveolar fluid clearance in a rat model of acute lung injury.Iranian journal of basic medical sciences · 2022Article
- Design and Rationale of the Sevoflurane for Sedation in Acute Respiratory Distress Syndrome (SESAR) Randomized Controlled Trial.Journal of clinical medicine · 2022Article
- Ventilator-induced lung-injury in mouse models: Is there a trap?Laboratory animal research · 2021Review
- Nanoparticle delivery of microRNA-146a regulates mechanotransduction in lung macrophages and mitigates injury during mechanical ventilation.Nature communications · 2021Article
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14 authors at 1 institution in 2 countries.
Funding
Abstract
backgroundIsoflurane may be protective in preclinical models of lung injury, but its use in patients with lung injury remains controversial and the mechanism of its protective effects remains unclear. The authors hypothesized that this protection is mediated at the level of alveolar tight junctions and investigated the possibility in a two-hit model of lung injury that mirrors human acute respiratory distress syndrome.
methodsWild-type mice were treated with isoflurane 1 h after exposure to nebulized endotoxin (n = 8) or saline control (n = 9) and then allowed to recover for 24 h before mechanical ventilation (MV; tidal volume, 15 ml/kg, 2 h) producing ventilator-induced lung injury. Mouse lung epithelial cells were similarly treated with isoflurane 1 h after exposure to lipopolysaccharide. Cells were cyclically stretched the following day to mirror the MV protocol used in vivo.
resultsMice treated with isoflurane following exposure to inhaled endotoxin and before MV exhibited significantly less physiologic lung dysfunction. These effects appeared to be mediated by decreased vascular leak, but not altered inflammatory indices. Mouse lung epithelial cells treated with lipopolysaccharide and cyclic stretch and lungs harvested from mice after treatment with lipopolysaccharide and MV had decreased levels of a key tight junction protein (i.e., zona occludens 1) that was rescued by isoflurane treatment.
conclusionsIsoflurane rescued lung injury induced by a two-hit model of endotoxin exposure followed by MV by maintaining the integrity of the alveolar-capillary barrier possibly by modulating the expression of a key tight junction protein.
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