Trial reportScientific reports2015
Climate induces seasonality in pneumococcal transmission.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 31 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
31 citing papers in PubMed, 58 citations in OpenAlex.
- Pneumococcal vaccine serotype-specific antibody levels among PCV-unvaccinated children in Karnataka, India.Medical microbiology and immunology · 2026Article
- Prevalence and determinants of nasal carriage of penicillin non-susceptibleThe Lancet regional health. Western Pacific · 2025Article
- Article
- The spatio-temporal distribution of acute encephalitis syndrome and its association with climate and landcover in Vietnam.BMC infectious diseases · 2023Article
- Pneumococcal nasopharyngeal carriage in children under 5 years of age at an outpatient healthcare facility in Novi Sad, Serbia during the COVID-19 pandemic.IJID regions · 2022Article
- Influence of sex, season and environmental air quality on experimental human pneumococcal carriage acquisition: a retrospective cohort analysis.ERJ open research · 2022Article
- Approximate likelihood-based estimation method of multiple-type pathogen interactions: An application to longitudinal pneumococcal carriage data.Statistics in medicine · 2022Article
- Non-diphtheriae Corynebacterium species are associated with decreased risk of pneumococcal colonization during infancy.The ISME journal · 2022Article
- Widespread sharing of pneumococcal strains in a rural African setting: proximate villages are more likely to share similar strains that are carried at multiple timepoints.Microbial genomics · 2022Article
- Article
- The nose is the best niche for detection of experimental pneumococcal colonisation in adults of all ages, using nasal wash.Scientific reports · 2021Article
- The Upper Airway Microbiota, Environmental Exposures, Inflammation, and Disease.Medicina (Kaunas, Lithuania) · 2021Review
- Bacteraemia variation during the COVID-19 pandemic; a multi-centre UK secondary care ecological analysis.BMC infectious diseases · 2021Article
- Prevalence and antimicrobial resistance profiles of respiratory microbial flora in African children with HIV-associated chronic lung disease.BMC infectious diseases · 2021Article
- Article
- Infant Pneumococcal Carriage in Belgium Not Affected by COVID-19 Containment Measures.Frontiers in cellular and infection microbiology · 2021Article
- Study on the correlation between ambient environment-meteorological factors and the number of visits of acute otitis media, Lanzhou, China.Journal of otology · 2020Article
- Within-host microevolution of Streptococcus pneumoniae is rapid and adaptive during natural colonisation.Nature communications · 2020Article
- Article
- Impact of 13-Valent Pneumococcal Conjugate Vaccine on Colonization and Invasive Disease in Cambodian Children.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2020Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 5 institutions in 3 countries.
Funding
Abstract
Streptococcus pneumoniae is a significant human pathogen and a leading cause of infant mortality in developing countries. Considerable global variation in the pneumococcal carriage prevalence has been observed and the ecological factors contributing to it are not yet fully understood. We use data from a cohort of infants in Asia to study the effects of climatic conditions on both acquisition and clearance rates of the bacterium, finding significantly higher transmissibility during the cooler and drier months. Conversely, the length of a colonization period is unaffected by the season. Independent carriage data from studies conducted on the African and North American continents suggest similar effects of the climate on the prevalence of this bacterium, which further validates the obtained results. Further studies could be important to replicate the findings and explain the mechanistic role of cooler and dry air in the physiological response to nasopharyngeal acquisition of the pneumococcus.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.