Evidence map›Paper›PMID 26067754›Full record

ArticleNature communications2015

Regulation of nucleotide metabolism by mutant p53 contributes to its gain-of-function activities.

Madhusudhan Kollareddy, Elizabeth Dimitrova, Krishna C Vallabhaneni, Adriano Chan, Thuc Le, Krishna M Chauhan, Zunamys I Carrero, Gopalakrishnan Ramakrishnan, Kounosuke Watabe, Ygal Haupt and 6 more

Erratum issuedOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 94 papers.

0numbers the graph read from it
0cells of the map it votes in
94citing papers in PubMed
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

94 citing papers in PubMed, 121 citations in OpenAlex.

  1. GTP biosynthesis is a therapeutic vulnerability in Rac1-mutant melanoma.bioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Revisiting tumor immunogenicity through the lens of mutant p53: Implications for cancer immunotherapy.Apoptosis : an international journal on programmed cell death · 2026
    Review
  4. Review
  5. Article
  6. Review
  7. Article
  8. Metabolic adaptations of brain metastasis.Nature reviews. Cancer · 2025
    Review
  9. Article
  10. Pyrimidine metabolism reshapes immune microenvironment and implies poor prognosis in glioma.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2025
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Mutant TP53 promotes invasion of lung cancer cells by regulating desmoglein 3.Journal of cancer research and clinical oncology · 2024
    Article
  16. Review
  17. Article
  18. Article
  19. Review
  20. Article

34 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 4 institutions in 2 countries.

Madhusudhan KollareddyDepartment of Biochemistry and University of Mississippi Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Elizabeth DimitrovaDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA.
Krishna C VallabhaneniDepartment of Biochemistry and University of Mississippi Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Adriano ChanDepartment of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Thuc LeDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA.
Krishna M ChauhanDepartment of Biochemistry and University of Mississippi Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Zunamys I CarreroDepartment of Biochemistry and University of Mississippi Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Gopalakrishnan RamakrishnanDepartment of Biochemistry and University of Mississippi Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Kounosuke WatabeDepartment of Microbiology and University of Mississippi Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Ygal Haupt1] Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Locked Bag, East Melbourne, Victoria 3002, Australia [2] Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Victoria, Australia [3] Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Sue Haupt1] Tumour Suppression Laboratory, Peter MacCallum Cancer Centre, Locked Bag, East Melbourne, Victoria 3002, Australia [2] Department of Pathology, The University of Melbourne, Parkville, Victoria 3010, Australia.
Radhika PochampallyDepartment of Biochemistry and University of Mississippi Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Gerard R BossDepartment of Medicine, University of California, San Diego, La Jolla, California 92093, USA.
Damian G RomeroDepartment of Biochemistry and University of Mississippi Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
Caius G RaduDepartment of Molecular and Medical Pharmacology, University of California, Los Angeles, California 90095, USA.
Luis A MartinezDepartment of Biochemistry and University of Mississippi Cancer Institute, University of Mississippi Medical Center, Jackson, Mississippi 39216, USA.
University of Mississippi Medical Center · USUniversity of California, Los Angeles · USPeter MacCallum Cancer Centre · AUUniversity of California, San Diego · US

Funding

Women's CancersP30CA016042 · NCI · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI Samuel Wheeler French · 1985 to 2026
$134.5M
Transcriptional Regulations of Oncongenic Properties of Mutant P53R01CA166974 · NCI · UNIVERSITY OF MISSISSIPPI MED CTR · PI Luis Alfonso Martinez · 2013 to 2026
$3.3M
Roles of hyaluronic acid in cancer stem cell nicheR01CA173499 · NCI · WAKE FOREST UNIVERSITY HEALTH SCIENCES · PI WATABE, KOUNOSUKE · 2014 to 2018
$2.3M
NCI NIH HHS CA166974-01A1NCI NIH HHS P30 CA016042NCI NIH HHS R01 CA166974NCI NIH HHS R01 CA173499
6 · The paper itself

Abstract

Mutant p53 (mtp53) is an oncogene that drives cancer cell proliferation. Here we report that mtp53 associates with the promoters of numerous nucleotide metabolism genes (NMG). Mtp53 knockdown reduces NMG expression and substantially depletes nucleotide pools, which attenuates GTP-dependent protein activity and cell invasion. Addition of exogenous guanosine or GTP restores the invasiveness of mtp53 knockdown cells, suggesting that mtp53 promotes invasion by increasing GTP. In addition, mtp53 creates a dependency on the nucleoside salvage pathway enzyme deoxycytidine kinase for the maintenance of a proper balance in dNTP pools required for proliferation. These data indicate that mtp53-harbouring cells have acquired a synthetic sick or lethal phenotype relationship with the nucleoside salvage pathway. Finally, elevated expression of NMG correlates with mutant p53 status and poor prognosis in breast cancer patients. Thus, mtp53's control of nucleotide biosynthesis has both a driving and sustaining role in cancer development.

Indexed as

AnimalsBlotting, WesternBrain NeoplasmsBreast NeoplasmsCell CycleCell Line, TumorCell ProliferationDeoxycytidine KinaseFemaleGene Expression Regulation, NeoplasticGene Knockdown TechniquesGuanosine TriphosphateHumansImmunoprecipitationKaplan-Meier EstimateMiceDeoxycytidine KinaseGuanosine TriphosphateNucleosidesNucleotidesTP53 protein, humanTumor Suppressor Protein p53

Identifiers

PMID26067754
PMCPMC4467467
OpenAlexW2266420598

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.