Evidence map›Paper›PMID 26067652›Full record

ArticleBMC plant biology2015

The effect of red light and far-red light conditions on secondary metabolism in agarwood.

Tony Chien-Yen Kuo, Chuan-Hung Chen, Shu-Hwa Chen, I-Hsuan Lu, Mei-Ju Chu, Li-Chun Huang, Chung-Yen Lin, Chien-Yu Chen, Hsiao-Feng Lo, Shih-Tong Jeng and 1 more

Abstract read
In one paragraph

Article in BMC plant biology, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Phenolic Acids and Amaryllidaceae Alkaloids Profiles inMolecules (Basel, Switzerland) · 2023
    Article
  7. Article
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  9. Genome-wide detection and classification of terpene synthase genes inPhysiology and molecular biology of plants : an international journal of functional plant biology · 2021
    Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. Antiallergic Phorbol Ester from the Seeds of Aquilaria malaccensis.International journal of molecular sciences · 2016
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Tony Chien-Yen KuoInstitute of Plant and Microbial Biology, Academia Sinica, 128 Sec. 2, Academia Rd, 11529, Nankang, Taipei, Taiwan. tony.cy.kuo@gmail.com.
Chuan-Hung ChenInstitute of Plant and Microbial Biology, Academia Sinica, 128 Sec. 2, Academia Rd, 11529, Nankang, Taipei, Taiwan. tim19850301@gmail.com.
Shu-Hwa ChenInstitute of Information Science, Academia Sinica, Taipei, 115, Taiwan. sophia@iis.sinica.edu.tw.
I-Hsuan LuInstitute of Information Science, Academia Sinica, Taipei, 115, Taiwan. lindalu@iis.sinica.edu.tw.
Mei-Ju ChuInstitute of Plant and Microbial Biology, Academia Sinica, 128 Sec. 2, Academia Rd, 11529, Nankang, Taipei, Taiwan. meiju@gate.sinica.edu.tw.
Li-Chun HuangInstitute of Plant and Microbial Biology, Academia Sinica, 128 Sec. 2, Academia Rd, 11529, Nankang, Taipei, Taiwan. bolch@gate.sinica.edu.tw.
Chung-Yen LinInstitute of Information Science, Academia Sinica, Taipei, 115, Taiwan. cylin@iis.sinica.edu.tw.
Chien-Yu ChenDepartment of Bio-industrial Mechatronics Engineering, National Taiwan University, Taipei, 106, Taiwan. cychen@mars.csie.ntu.edu.tw.
Hsiao-Feng LoDepartment of Horticulture and Landscape Architecture, National Taiwan University, Taipei, 106, Taiwan. hflo@ntu.edu.tw.
Shih-Tong JengInstitute of Plant Biology, College of Life Science, National Taiwan University, Taipei, 106, Taiwan. stjeng@ntu.edu.tw.
Long-Fang O ChenInstitute of Plant and Microbial Biology, Academia Sinica, 128 Sec. 2, Academia Rd, 11529, Nankang, Taipei, Taiwan. ochenlf@gate.sinica.edu.tw.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAgarwood, a heartwood derived from Aquilaria trees, is a valuable commodity that has seen prevalent use among many cultures. In particular, it is widely used in herbal medicine and many compounds in agarwood are known to exhibit medicinal properties. Although there exists much research into medicinal herbs and extraction of high value compounds, few have focused on increasing the quantity of target compounds through stimulation of its related pathways in this species.

resultsIn this study, we observed that cucurbitacin yield can be increased through the use of different light conditions to stimulate related pathways and conducted three types of high-throughput sequencing experiments in order to study the effect of light conditions on secondary metabolism in agarwood. We constructed genome-wide profiles of RNA expression, small RNA, and DNA methylation under red light and far-red light conditions. With these profiles, we identified a set of small RNA which potentially regulates gene expression via the RNA-directed DNA methylation pathway.

conclusionsWe demonstrate that light conditions can be used to stimulate pathways related to secondary metabolism, increasing the yield of cucurbitacins. The genome-wide expression and methylation profiles from our study provide insight into the effect of light on gene expression for secondary metabolism in agarwood and provide compelling new candidates towards the study of functional secondary metabolic components.

Indexed as

LightBase SequenceCluster AnalysisCucurbitacinsDNA MethylationGene Expression Regulation, PlantGene OntologySecondary MetabolismSequence Analysis, RNAThymelaeaceaeWoodCucurbitacins

Identifiers

PMID26067652
PMCPMC4464252

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.