Trial reportScientific reports2015
Emotional Eating Phenotype is Associated with Central Dopamine D2 Receptor Binding Independent of Body Mass Index.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 2 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- Effects of bariatric surgery and dietary interventions for obesity on brain neurotransmitter systems and metabolism: A systematic review of positron emission tomography (PET) and single-photon emission computed tomography (SPECT) studies.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2023Pooled it
- Striatal dopamine D2-like receptors availability in obesity and its modulation by bariatric surgery: a systematic review and meta-analysis.Scientific reports · 2023Pooled it
- Dietary fat restriction affects brain reward regions in a randomized crossover trial.JCI insight · 2023Trial
- Beyond Pleasure: Unraveling the Multifaceted Role of Dopamine in Obesity and Metabolic Regulation.Current obesity reports · 2026Review
- PET/fMRI demonstrates that bariatric surgery may reverse striatal dopaminergic dysfunction in women with obesity.Communications medicine · 2025Article
- Central dopamine receptors: Radiotracers unveiling the Role of dopaminergic tone in obesity.Journal of molecular medicine (Berlin, Germany) · 2025Review
- Relationship between emotional eating and nutritional intake in adult women with overweight and obesity: a cross-sectional study.Nutrition journal · 2024Article
- Article
- Cannabis use following bariatric surgery is associated with anxiety and maladaptive eating.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2024Article
- Molecular Imaging of Central Dopamine in Obesity: A Qualitative Review across Substrates and Radiotracers.Brain sciences · 2022Review
- Food craving-like episodes during pregnancy are mediated by accumbal dopaminergic circuits.Nature metabolism · 2022Article
- The interplay between prolactin and cardiovascular disease.Frontiers in endocrinology · 2022Review
- Nucleus accumbens microstructure mediates the relationship between obesity and eating behavior in adults.Obesity (Silver Spring, Md.) · 2021Article
- Dopamine DDrug and alcohol dependence · 2021Article
- Cerebral glucose metabolism differs according to future weight change.Brain imaging and behavior · 2020Article
- The Effect of Food Composition and Behavior on Neurobiological Response to Food: a Review of Recent Research.Current nutrition reports · 2020Review
- Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging.Frontiers in human neuroscience · 2019Article
- Multi-behavioral obesogenic phenotypes among school-aged boys and girls along the birth weight continuum.PloS one · 2019Article
- Food addiction: a valid concept?Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Review
- Persistent effects of obesity: a neuroplasticity hypothesis.Annals of the New York Academy of Sciences · 2018Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors.
Funding
Abstract
PET studies have provided mixed evidence regarding central D2/D3 dopamine receptor binding and its relationship with obesity as measured by body mass index (BMI). Other aspects of obesity may be more tightly coupled to the dopaminergic system. We characterized obesity-associated behaviors and determined if these related to central D2 receptor (D2R) specific binding independent of BMI. Twenty-two obese and 17 normal-weight participants completed eating- and reward-related questionnaires and underwent PET scans using the D2R-selective and nondisplaceable radioligand (N-[(11)C]methyl)benperidol. Questionnaires were grouped by domain (eating related to emotion, eating related to reward, non-eating behavior motivated by reward or sensitivity to punishment). Normalized, summed scores for each domain were compared between obese and normal-weight groups and correlated with striatal and midbrain D2R binding. Compared to normal-weight individuals, the obese group self-reported higher rates of eating related to both emotion and reward (p<0.001), greater sensitivity to punishment (p=0.06), and lower non-food reward behavior (p<0.01). Across normal-weight and obese participants, self-reported emotional eating and non-food reward behavior positively correlated with striatal (p<0.05) and midbrain (p<0.05) D2R binding, respectively. In conclusion, an emotional eating phenotype may reflect altered central D2R function better than other commonly used obesity-related measures such as BMI.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.