ArticleInvestigative ophthalmology & visual science2015
Corneal Anesthesia With Site 1 Sodium Channel Blockers and Dexmedetomidine.
Article in Investigative ophthalmology & visual science, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 23 citations in OpenAlex.
- Prevention of dexmedetomidine on postoperative delirium and early postoperative cognitive dysfunction in elderly patients undergoing hepatic lobectomy.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2022Trial
- Materials for Controlled Release of Local Anesthetics.ChemMedChem · 2023Review
- Voltage-Gated Sodium Channels: A Prominent Target of Marine Toxins.Marine drugs · 2021Review
- Effects of topical application of tramadol with/without dexmedetomidine and proparacaine on corneal sensitivity in rats.International ophthalmology · 2021Article
- Pentadecapeptide BPC 157 shortens duration of tetracaine- and oxybuprocaine-induced corneal anesthesia in rats.Acta clinica Croatica · 2020Article
- Prolonged Duration Topical Corneal Anesthesia With the Cationic Lidocaine Derivative QX-314.Translational vision science & technology · 2019Article
- Transtympanic Delivery of Local Anesthetics for Pain in Acute Otitis Media.Molecular pharmaceutics · 2019Article
- Ciprofloxacin-lidocaine-based hydrogel: development, characterization, and in vivo evaluation in a second-degree burn model.Drug delivery and translational research · 2018Article
- Long-acting liposomal corneal anesthetics.Biomaterials · 2018Article
- Prolonged Duration Local Anesthesia Using Liposomal Bupivacaine Combined With Liposomal Dexamethasone and Dexmedetomidine.Anesthesia and analgesia · 2018Article
- Multiply repeatable and adjustable on-demand phototriggered local anesthesia.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Ultrasensitive Phototriggered Local Anesthesia.Nano letters · 2017Article
- Ultrasound-triggered local anaesthesia.Nature biomedical engineering · 2017Article
- Repeatable and adjustable on-demand sciatic nerve block with phototriggerable liposomes.Proceedings of the National Academy of Sciences of the United States of America · 2015Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
purposeAmino-amide or amino-ester local anesthetics, which are currently used for topical ocular anesthesia, are short acting and may delay corneal healing with long-term use. In contrast, site 1 sodium channel blockers (S1SCBs) are potent local anesthetics with minimal adverse tissue reaction. In this study, we examined topical local anesthesia with two S1SCBs, tetrodotoxin (TTX) or saxitoxin (STX) individually or in combination with α2-adrenergic receptor agonists (dexmedetomidine or clonidine), and compared them with the amino-ester ocular anesthetic proparacaine. The effect of test solutions on corneal healing was also studied.
methodsSolutions of TTX ± dexmedetomidine, TTX ± clonidine, STX ± dexmedetomidine, dexmedetomidine, or proparacaine were applied to the rat cornea. Tactile sensitivity was measured by recording the blink response to probing of the cornea with a Cochet-Bonnet esthesiometer. The duration of corneal anesthesia was calculated. Cytotoxicity from anesthetic solutions was measured in vitro. The effect on corneal healing was measured in vivo after corneal debridement followed by repeated drug administration.
resultsAddition of dexmedetomidine to TTX or STX significantly prolonged corneal anesthesia beyond that of either drug alone, whereas clonidine did not. Tetrodotoxin or STX coadministered with dexmedetomidine resulted in two to three times longer corneal anesthesia than did proparacaine. S1SCB-dexmedetomidine formulations were not cytotoxic. Corneal healing was not delayed significantly by any of the test solutions.
conclusionsCoadministration of S1SCBs with dexmedetomidine provided prolonged corneal anesthesia without delaying corneal wound healing. Such formulations may be useful for the management of acute surgical and nonsurgical corneal pain.
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Registered trials
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