ArticleNature communications2015
Graphene-enabled electron microscopy and correlated super-resolution microscopy of wet cells.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 50 papers.
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Who cites it
50 citing papers in PubMed.
- Class-I myosin responds to changes in membrane tension during clathrin-mediated endocytosis in human induced pluripotent stem cells.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- Graphene-Based Liquid Cell Designs for In Situ Liquid-Phase Transmission Electron Microscopy: Recent Developments and Perspectives.Small science · 2025Review
- Direct microsecond wide-field single-molecule tracking and super-resolution mapping via CCD vertical shift.Nature communications · 2025Article
- Fast and robust drift correction for single-molecule localization microscopy.Nature communications · 2025Article
- A comprehensive review of graphene-based biosensors: Fabrication, applications, characterization and future perspectives-A review.APL bioengineering · 2025Review
- A chemical-genetic approach to target voltage-sensitive fluorophores to mitochondria.Mitochondrial communications · 2025Article
- Single-molecule diffusivity quantification inProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Hypersensitivity of the vimentin cytoskeleton to net-charge states and Coulomb repulsion.bioRxiv : the preprint server for biology · 2024Article
- Ectopic Expression of a Truncated Isoform of Hair Keratin 81 in Breast Cancer Alters Biophysical Characteristics to Promote Metastatic Propensity.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2024Article
- Photothermal Microscopy and Spectroscopy with Nanomechanical Resonators.The journal of physical chemistry. C, Nanomaterials and interfaces · 2023Review
- Mitochondrial uncouplers impair human sperm motility without altering ATP content†.Biology of reproduction · 2023Article
- Review
- Branched actin networks are organized for asymmetric force production during clathrin-mediated endocytosis in mammalian cells.Nature communications · 2022Article
- Load adaptation by endocytic actin networks.Molecular biology of the cell · 2022Article
- The endoplasmic reticulum adopts two distinct tubule forms.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
- Recent Developments in Correlative Super-Resolution Fluorescence Microscopy and Electron Microscopy.Molecules and cells · 2022Review
- Determinants of synapse diversity revealed by super-resolution quantal transmission and active zone imaging.Nature communications · 2022Article
- Super-Resolution Imaging with Graphene.Biosensors · 2021Review
- Genome-wide CRISPRi/a screens in human neurons link lysosomal failure to ferroptosis.Nature neuroscience · 2021Article
- Mass spectrometry imaging of untreated wet cell membranes in solution using single-layer graphene.Nature methods · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The application of electron microscopy to hydrated biological samples has been limited by high-vacuum operating conditions. Traditional methods utilize harsh and laborious sample dehydration procedures, often leading to structural artefacts and creating difficulties for correlating results with high-resolution fluorescence microscopy. Here, we utilize graphene, a single-atom-thick carbon meshwork, as the thinnest possible impermeable and conductive membrane to protect animal cells from vacuum, thus enabling high-resolution electron microscopy of wet and untreated whole cells with exceptional ease. Our approach further allows for facile correlative super-resolution and electron microscopy of wet cells directly on the culturing substrate. In particular, individual cytoskeletal actin filaments are resolved in hydrated samples through electron microscopy and well correlated with super-resolution results.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.