Evidence map›Paper›PMID 26066675›Full record

ArticleThe Journal of clinical endocrinology and metabolism2015

Dietary Carbohydrate Intake Does Not Impact Insulin Resistance or Androgens in Healthy, Eumenorrheic Women.

Lindsey A Sjaarda, Enrique F Schisterman, Karen C Schliep, Torie Plowden, Shvetha M Zarek, Edwina Yeung, Jean Wactawski-Wende, Sunni L Mumford

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of clinical endocrinology and metabolism, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed, 1 pooled it
3.8field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 1 synthesis or guideline pooled it, 22 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Development of a nutrition screening tool to identify need for dietetic intervention in female infertility.Journal of human nutrition and dietetics : the official journal of the British Dietetic Association · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 1 country.

Lindsey A SjaardaDivision of Intramural Population Health Research (L.A.S., E.F.S., K.C.S., T.P., S.M.Z., E.Y., S.L.M.) and Program of Reproductive and Adult Endocrinology (T.P., S.M.Z.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; and Department of Epidemiology and Environmental Health (J.W.W.), School of Public Health and Health Professions, University at Buffalo, Buffalo, New York 14214.
Enrique F SchistermanDivision of Intramural Population Health Research (L.A.S., E.F.S., K.C.S., T.P., S.M.Z., E.Y., S.L.M.) and Program of Reproductive and Adult Endocrinology (T.P., S.M.Z.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; and Department of Epidemiology and Environmental Health (J.W.W.), School of Public Health and Health Professions, University at Buffalo, Buffalo, New York 14214.
Karen C SchliepDivision of Intramural Population Health Research (L.A.S., E.F.S., K.C.S., T.P., S.M.Z., E.Y., S.L.M.) and Program of Reproductive and Adult Endocrinology (T.P., S.M.Z.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; and Department of Epidemiology and Environmental Health (J.W.W.), School of Public Health and Health Professions, University at Buffalo, Buffalo, New York 14214.
Torie PlowdenDivision of Intramural Population Health Research (L.A.S., E.F.S., K.C.S., T.P., S.M.Z., E.Y., S.L.M.) and Program of Reproductive and Adult Endocrinology (T.P., S.M.Z.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; and Department of Epidemiology and Environmental Health (J.W.W.), School of Public Health and Health Professions, University at Buffalo, Buffalo, New York 14214.
Shvetha M ZarekDivision of Intramural Population Health Research (L.A.S., E.F.S., K.C.S., T.P., S.M.Z., E.Y., S.L.M.) and Program of Reproductive and Adult Endocrinology (T.P., S.M.Z.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; and Department of Epidemiology and Environmental Health (J.W.W.), School of Public Health and Health Professions, University at Buffalo, Buffalo, New York 14214.
Edwina YeungDivision of Intramural Population Health Research (L.A.S., E.F.S., K.C.S., T.P., S.M.Z., E.Y., S.L.M.) and Program of Reproductive and Adult Endocrinology (T.P., S.M.Z.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; and Department of Epidemiology and Environmental Health (J.W.W.), School of Public Health and Health Professions, University at Buffalo, Buffalo, New York 14214.
Jean Wactawski-WendeDivision of Intramural Population Health Research (L.A.S., E.F.S., K.C.S., T.P., S.M.Z., E.Y., S.L.M.) and Program of Reproductive and Adult Endocrinology (T.P., S.M.Z.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; and Department of Epidemiology and Environmental Health (J.W.W.), School of Public Health and Health Professions, University at Buffalo, Buffalo, New York 14214.
Sunni L MumfordDivision of Intramural Population Health Research (L.A.S., E.F.S., K.C.S., T.P., S.M.Z., E.Y., S.L.M.) and Program of Reproductive and Adult Endocrinology (T.P., S.M.Z.), Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, Maryland 20892; and Department of Epidemiology and Environmental Health (J.W.W.), School of Public Health and Health Professions, University at Buffalo, Buffalo, New York 14214.
Office of Extramural Research · USEunice Kennedy Shriver National Institute of Child Health and Human Development · USNational Institutes of Health · USUniversity at Buffalo, State University of New York · US

Funding

Oxidative Stress, Hormones and Women s HealthZIAHD008762 · NICHD · EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT · PI PERKINS, NEIL · 2009 to 2025
$3.1M
Intramural NIH HHSNICHD NIH HHS HHSN275201100002CNICHD NIH HHS HHSN275201100002GPHS HHS 1 HHSN27500001PHS HHS HHSN275200403394CPHS HHS HHSN275201100002I
6 · The paper itself

Abstract

contextDiet is proposed to contribute to androgen-related reproductive dysfunction.

objectiveThis study evaluated the association between dietary macronutrient intake, carbohydrate fraction intake, and overall diet quality on androgens and related hormones, including anti-Müllerian hormone (AMH) and insulin, in healthy, regularly menstruating women.

designThis was a prospective cohort study from 2005 and 2007.

settingThe study was conducted at the University at Buffalo, western New York State, USA.

participantsParticipants were 259 eumenorrheic women without a self-reported history of infertility, polycystic ovary syndrome (PCOS), or other endocrine disorder.

main outcome measuresA 24-hour dietary recall was administered 4 times per menstrual cycle, and hormones were measured 5 to 8 times per cycle for 1 (n = 9) or 2 (n = 250) cycles per woman (n = 509 cycles). Associations between the dietary intake of carbohydrates (starch, sugar, sucrose, and fiber), macronutrients, overall diet quality and hormones (insulin, AMH, and total and free testosterone), as well as the relationship of dietary intake with occurrences of high total testosterone combined with high AMH (fourth quartile of each), ie, the "PCOS-like phenotype," were assessed.

resultsNo significant relationships were identified between dietary intake of carbohydrates, percent calories from any macronutrient or overall diet quality (ie, Mediterranean diet score) and relevant hormones (insulin, AMH, and total and free testosterone). Likewise, no significant relationships were identified between dietary factors and the occurrence of a subclinical PCOS-like phenotype.

conclusionsDespite evidence of a subclinical continuum of a PCOS-related phenotype of elevated androgens and AMH related to sporadic anovulation identified in previous studies, dietary carbohydrate and diet quality do not appear to relate to these subclinical endocrine characteristics in women without overt PCOS.

Indexed as

Insulin ResistanceAdolescentAdultAndrogensCohort StudiesDietDietary CarbohydratesDiet RecordsEatingFemaleHealthHumansMenstrual CyclePolycystic Ovary SyndromeYoung AdultAndrogensDietary Carbohydrates

Identifiers

PMID26066675
PMCPMC4524988
OpenAlexW2178442036

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.