ArticleAnnals of biomedical engineering2015
Transdermal Delivery of Functional Collagen Via Polyvinylpyrrolidone Microneedles.
Article in Annals of biomedical engineering, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 40 citations in OpenAlex.
- Recent progress and clinical applications of advanced biomaterials in cosmetic surgery.Regenerative biomaterials · 2023Review
- Article
- Polymeric-based microneedle arrays as potential platforms in the development of drugs delivery systems.Journal of advanced research · 2020Review
- Microneedle-Based Delivery: An Overview of Current Applications and Trends.Pharmaceutics · 2020Review
- A simple and cost-effective approach to fabricate tunable length polymeric microneedle patches for controllable transdermal drug delivery.RSC advances · 2020Article
- Bases for Treating Skin Aging With Artificial Mitochondrial Transfer/Transplant (AMT/T).Frontiers in bioengineering and biotechnology · 2020Article
- Smart Microneedles for Therapy and Diagnosis.Research (Washington, D.C.) · 2020Review
- Abalone Collagen Extracts Potentiate Stem Cell Properties of Human Epidermal Keratinocytes.Marine drugs · 2019Article
- Topical Administration of Ibuprofen for Injured Athletes: Considerations, Formulations, and Comparison to Oral Delivery.Sports medicine - open · 2017Review
Corrections and comments
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Authors and funding
10 authors at 4 institutions in 2 countries.
Funding
Abstract
Collagen makes up a large proportion of the human body, particularly the skin. As the body ages, collagen content decreases, resulting in wrinkled skin and decreased wound healing capabilities. This paper presents a method of delivering type I collagen into porcine and human skin utilizing a polyvinylpyrrolidone microneedle delivery system. The microneedle patches were made with concentrations of 1, 2, 4, and 8% type I collagen (w/w). Microneedle structures and the distribution of collagen were characterized using scanning electron microscopy and confocal microscopy. Patches were then applied on the porcine and human skin, and their effectiveness was examined using fluorescence microscopy. The results illustrate that this microneedle delivery system is effective in delivering collagen I into the epidermis and dermis of porcine and human skin. Since the technique presented in this paper is quick, safe, effective and easy, it can be considered as a new collagen delivery method for cosmetic and therapeutic applications.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.