ArticleEye (London, England)2015
The association of vitamin D deficiency with tear break-up time and Schirmer testing in non-Sjögren dry eye.
Article in Eye (London, England), 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 2 of them syntheses that pooled it.
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Who cites it
29 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- The Efficacy of Oral Vitamin Supplementation in Dry Eye Disease: A Systematic Review.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026Pooled it
- Vitamin D and Ocular Diseases: A Systematic Review.International journal of molecular sciences · 2022Pooled it
- A prospective study to assess the role of vitamin D individually and in combination with cyclosporine in the treatment of dry eye in patients with deficient serum 25(OH)D levels.Indian journal of ophthalmology · 2020Trial
- Vitamin D Deficiency and Dry Eye Disease: A Retrospective Cohort Study.American journal of ophthalmology · 2026Article
- Serum 25-hydroxyvitamin D and tear-film stability in dry eye disease: A case-control correlation study.Bioinformation · 2026Article
- Association between systemic medication use and severity of dry eye signs and symptoms in the DRy eye assessment and management (DREAM) study.The ocular surface · 2024Article
- Management of Corneal Haze After Photorefractive Keratectomy.Ophthalmology and therapy · 2023Review
- Dry eye disease: identification and therapeutic strategies for primary care clinicians and clinical specialists.Annals of medicine · 2023Review
- Effects of Topical 1,25 and 24,25 Vitamin D on Diabetic, Vitamin D Deficient and Vitamin D Receptor Knockout Mouse Corneal Wound Healing.Biomolecules · 2023Article
- Study of correlation between vitamin D3 levels and dry eye.Indian journal of ophthalmology · 2023Article
- Vitamin D and eye: Current evidence and practice guidelines.Indian journal of ophthalmology · 2023Review
- Dry Eye Disease: What Is the Role of Vitamin D?International journal of molecular sciences · 2023Review
- Article
- Vitamin D, the Vitamin D Receptor, Calcitriol Analogues and Their Link with Ocular Diseases.Nutrients · 2022Review
- Resolution of acquired palmoplantar keratoderma and scurvy after treatment of multivitamin deficiencies.JAAD case reports · 2022Article
- A study of the association between Vitamin D deficiency and Dry Eye Syndrome (DES) in the Indian population.Indian journal of ophthalmology · 2022Observational
- Comparison of vitamin D levels between patients with pterygium and healthy subjects.International ophthalmology · 2021Article
- Clinical outcomes of ocular surface in patients treated with vitamin D oral replacement.Arquivos brasileiros de oftalmologia · 2020Article
- Aqueous humor and serum 25-Hydroxyvitamin D levels in patients with cataracts.BMC ophthalmology · 2020Article
- Association Between Single Nucleotide Polymorphisms in the Vitamin D Receptor and Incidence of Dry Eye Disease in Chinese Han Population.Medical science monitor : international medical journal of experimental and clinical research · 2019Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo investigate the effect of vitamin D deficiency on tear break-up time (TBUT) and Schirmer test scores and to assess their relationship in non-Sjögren dry-eye patients.
methodsThirty-four patients with serum vitamin D deficiency and 21 control subjects with normal vitamin D levels were included in this study. The TBUT and Schirmer-1 test without topical anesthesia were performed to all patients.
resultsThe mean TBUT were 5.18±2.15 and 7.36±3.10 s and Schirmer scores were 12.18±6.44 and 18.57±8.99 mm in the study and control groups, respectively. TBUT scores and Schirmer-1 results of the study group were significantly lower than the control group (P=0.01 and 0.007, respectively). The mean vitamin D levels were 11.50±1.8 ng/ml in the study group and 32.8±8.72 ng/ml in control group (P=0.001). Dry-eye symptoms were detected in all patients in the study group and 15% of the patients in the control group.
conclusionsWe demonstrated that vitamin D deficiency decreases the TBUT and Schirmer test values and may be associated with dry-eye symptoms in non-Sjögren syndrome.
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