ArticleJournal of visualized experiments : JoVE2015
Hybrid µCT-FMT imaging and image analysis.
Article in Journal of visualized experiments : JoVE, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 34 citations in OpenAlex.
- Histopathological biomarkers for predicting the tumour accumulation of nanomedicines.Nature biomedical engineering · 2024Article
- Application of the mineral-binding protein fetuin-A for the detection of calcified lesions.Theranostics · 2023Article
- The Interplay Between Biliary Occlusion and Liver Regeneration: Repeated Regeneration Stimuli Restore Biliary Drainage by Promoting Hepatobiliary Remodeling in a Rat Model.Frontiers in surgery · 2022Article
- Mixing Matrix-corrected Whole-body Pharmacokinetic Modeling Using Longitudinal Micro-computed Tomography and Fluorescence-mediated Tomography.Molecular imaging and biology · 2021Article
- Effects of Strontium-Doped β-Tricalcium Scaffold on Longitudinal Nuclear Factor-Kappa Beta and Vascular Endothelial Growth Factor Receptor-2 Promoter Activities during Healing in a Murine Critical-Size Bone Defect Model.International journal of molecular sciences · 2020Article
- A collagen-binding protein enables molecular imaging of kidney fibrosis in vivo.Kidney international · 2020Article
- Spatial heterogeneity of nanomedicine investigated by multiscale imaging of the drug, the nanoparticle and the tumour environment.Theranostics · 2020Review
- Multimodal and multiscale optical imaging of nanomedicine delivery across the blood-brain barrier upon sonopermeation.Theranostics · 2020Article
- A preclinical micro-computed tomography database including 3D whole body organ segmentations.Scientific data · 2018Article
- Standardization of Small Animal Imaging-Current Status and Future Prospects.Molecular imaging and biology · 2018Review
- X-ray computed tomography and its potential in ecological research: A review of studies and optimization of specimen preparation.Ecology and evolution · 2018Review
- Histidine-rich glycoprotein-induced vascular normalization improves EPR-mediated drug targeting to and into tumors.Journal of controlled release : official journal of the Controlled Release Society · 2018Article
- Targeting and Modulation of Liver Myeloid Immune Cells by Hard-Shell Microbubbles.Advanced biosystems · 2018Article
- Bone regeneration using composite non-demineralized xenogenic dentin with beta-tricalcium phosphate in experimental alveolar cleft repair in a rabbit model.Journal of translational medicine · 2017Article
- Novel synthetic adhesive as an effective alternative to Fibrin based adhesives.World journal of hepatology · 2017Article
- Article
- Post-weaning epiphysiolysis causes distal femur dysplasia and foreshortened hindlimbs in fetuin-A-deficient mice.PloS one · 2017Article
- Noninvasive Assessment of Elimination and Retention using CT-FMT and Kinetic Whole-body Modeling.Theranostics · 2017Article
- Visualization of Vascular and Parenchymal Regeneration after 70% Partial Hepatectomy in Normal Mice.Journal of visualized experiments : JoVE · 2016Article
- The necroptosis-inducing kinase RIPK3 dampens adipose tissue inflammation and glucose intolerance.Nature communications · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 3 institutions in 3 countries.
Funding
Abstract
Fluorescence-mediated tomography (FMT) enables longitudinal and quantitative determination of the fluorescence distribution in vivo and can be used to assess the biodistribution of novel probes and to assess disease progression using established molecular probes or reporter genes. The combination with an anatomical modality, e.g., micro computed tomography (µCT), is beneficial for image analysis and for fluorescence reconstruction. We describe a protocol for multimodal µCT-FMT imaging including the image processing steps necessary to extract quantitative measurements. After preparing the mice and performing the imaging, the multimodal data sets are registered. Subsequently, an improved fluorescence reconstruction is performed, which takes into account the shape of the mouse. For quantitative analysis, organ segmentations are generated based on the anatomical data using our interactive segmentation tool. Finally, the biodistribution curves are generated using a batch-processing feature. We show the applicability of the method by assessing the biodistribution of a well-known probe that binds to bones and joints.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.