Trial reportScientific reports2015
Novelty seeking is related to individual risk preference and brain activation associated with risk prediction during decision making.
Trial report in Scientific reports, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed.
- Sweet-taste liking is associated with preference for less risky and immediate rewards in economic decision-making.Frontiers in psychology · 2026Article
- Individual differences and motives for the acceptance of cognitive enhancement: A mixed-methods investigation.PloS one · 2026Article
- Frequency and leg stiffness adaptation in human vertical hopping before, during and after added load.The Journal of experimental biology · 2025Article
- Sex-Specific Impacts of Early Life Sleep Disruption: Ethanol Seeking, Social Interaction, and Anxiety Are Differentially Altered in Adolescent Prairie Voles.Developmental psychobiology · 2024Article
- The association between liking, learning and creativity in music.Scientific reports · 2024Article
- Behavioral, neurotransmitter and transcriptomic analyses in male and femaleFrontiers in behavioral neuroscience · 2024Article
- Using lickometry to infer differential contributions of salience network regions during compulsion-like alcohol drinking.Addiction neuroscience · 2023Article
- Others' Facial Expressions Influence Individuals Making Choices and Processing Feedback: The Event-Related Potential and Behavioral Evidence.International journal of environmental research and public health · 2022Article
- Aberrant resting-state functional connectivity of major depressive disorder with higher risk of suicide.PCN reports : psychiatry and clinical neurosciences · 2022Article
- Reward Processing in Novelty Seekers: A Transdiagnostic Psychiatric Imaging Biomarker.Biological psychiatry · 2021Article
- Intrinsic functional connectivity of blue and red brains: neurobiological evidence of different stress resilience between political attitudes.Scientific reports · 2020Article
- Effects of Developmental Nicotine Exposure on Frontal Cortical GABA-to-Non-GABA Neuron Ratio and Novelty-Seeking Behavior.Cerebral cortex (New York, N.Y. : 1991) · 2020Article
- Article
- Food Addiction in Eating Disorders and Obesity: Analysis of Clusters and Implications for Treatment.Nutrients · 2019Article
- High Self-Control Reduces Risk Preference: The Role of Connectivity Between Right Orbitofrontal Cortex and Right Anterior Cingulate Cortex.Frontiers in neuroscience · 2019Article
- Clinical Utility of the DriveFocus™ Intervention on Young Drivers With and Without Experience.Frontiers in public health · 2019Article
- Lack of Evidence That Neural Empathic Responses Are Blunted in Excessive Users of Violent Video Games: An fMRI Study.Frontiers in psychology · 2017Article
- Hemispheric Lateralization of Resting-State Functional Connectivity of the Anterior Insula: Association with Age, Gender, and a Novelty-Seeking Trait.Brain connectivity · 2016Article
- Novelty Seeking and Drug Addiction in Humans and Animals: From Behavior to Molecules.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2016Review
Corrections and comments
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Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Novelty seeking (NS) is a personality trait reflecting excitement in response to novel stimuli. High NS is usually a predictor of risky behaviour such as drug abuse. However, the relationships between NS and risk-related cognitive processes, including individual risk preference and the brain activation associated with risk prediction, remain elusive. In this fMRI study, participants completed the Tridimensional Personality Questionnaire to measure NS and performed a probabilistic decision making task. Using a mathematical model, we estimated individual risk preference. Brain regions associated with risk prediction were determined via fMRI. The NS score showed a positive correlation with risk preference and a negative correlation with the activation elicited by risk prediction in the right posterior insula (r-PI), left anterior insula (l-AI), right striatum (r-striatum) and supplementary motor area (SMA). Within these brain regions, only the activation associated with risk prediction in the r-PI showed a correlation with NS after controlling for the effect of risk preference. Resting-state functional connectivity between the r-PI and r-striatum/l-AI was negatively correlated with NS. Our results suggest that high NS may be associated with less aversion to risk and that the r-PI plays an important role in relating risk prediction to NS.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.