ArticleNature communications2015
The molecular origin of high DNA-repair efficiency by photolyase.
Article in Nature communications, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
25 citing papers in PubMed, 71 citations in OpenAlex.
- Efficient and selective energy transfer photoenzymes powered by visible light.Nature chemistry · 2025Article
- Quantum food and nutrition: Subatomic approaches to nourishment for health and well-being.Asia Pacific journal of clinical nutrition · 2025Article
- Noncanonical Amino Acids in Biocatalysis.Chemical reviews · 2024Review
- Understanding Active Photoprotection: DNA-Repair Enzymes and Antioxidants.Life (Basel, Switzerland) · 2024Review
- From Ground-State to Excited-State Activation Modes: Flavin-Dependent "Ene"-Reductases Catalyzed Non-natural Radical Reactions.Accounts of chemical research · 2024Review
- Photoinduced charge separation and DNA self-repair depend on sequence directionality and stacking pattern.Chemical science · 2024Article
- A Review: Multi-Omics Approach to Studying the Association between Ionizing Radiation Effects on Biological Aging.Biology · 2024Review
- Light-driven DNA repair at atomic and picosecond resolution revealed via time-resolved serial femtosecond crystallography.Clinical and translational medicine · 2024Article
- Reductive Photocycloreversion of Cyclobutane Dimers Triggered by Guanines.The Journal of organic chemistry · 2023Article
- Attosecond photoionization delays in the vicinity of molecular Feshbach resonances.Science advances · 2023Article
- Article
- 2,6-diaminopurine promotes repair of DNA lesions under prebiotic conditions.Nature communications · 2021Article
- Active-Site Environmental Factors Customize the Photophysics of Photoenzymatic Old Yellow Enzymes.The journal of physical chemistry. B · 2020Article
- Nonequilibrium dynamics of photoinduced forward and backward electron transfer reactions.The Journal of chemical physics · 2020Article
- Theoretical insights into the DNA repair function ofBiophysics and physicobiology · 2020Article
- A highly efficient and cost-effective recombinant production of a bacterial photolyase from the Antarctic isolate Hymenobacter sp. UV11.Extremophiles : life under extreme conditions · 2019Article
- Short-Range Electron Transfer in Reduced Flavodoxin: Ultrafast Nonequilibrium Dynamics Coupled with Protein Fluctuations.The journal of physical chemistry letters · 2018Article
- A Compass at Weak Magnetic Fields Using Thymine Dimer Repair.ACS central science · 2018Article
- A DNA-Based Magnetic Sensor.ACS central science · 2018Article
- Photolyase: Dynamics and electron-transfer mechanisms of DNA repair.Archives of biochemistry and biophysics · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The primary dynamics in photomachinery such as charge separation in photosynthesis and bond isomerization in sensory photoreceptor are typically ultrafast to accelerate functional dynamics and avoid energy dissipation. The same is also true for the DNA repair enzyme, photolyase. However, it is not known how the photoinduced step is optimized in photolyase to attain maximum efficiency. Here, we analyse the primary reaction steps of repair of ultraviolet-damaged DNA by photolyase using femtosecond spectroscopy. With systematic mutations of the amino acids involved in binding of the flavin cofactor and the cyclobutane pyrimidine dimer substrate, we report our direct deconvolution of the catalytic dynamics with three electron-transfer and two bond-breaking elementary steps and thus the fine tuning of the biological repair function for optimal efficiency. We found that the maximum repair efficiency is not enhanced by the ultrafast photoinduced process but achieved by the synergistic optimization of all steps in the complex repair reaction.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.