ReviewJournal of immunology research2015
Mechanisms of Bone Resorption in Periodontitis.
Review in Journal of immunology research, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 359 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
359 citing papers in PubMed, 3 syntheses or guidelines pooled it, 744 citations in OpenAlex.
- Clinical effect of immunomodulatory therapy in periodontitis: a systematic review and meta-analysis.Frontiers in bioengineering and biotechnology · 2025Pooled it
- Are asthma and allergy associated with increased root resorption following orthodontic treatment? A meta-analysis.PloS one · 2023Pooled it
- Meta-Analysis of Two Human RNA-seq Datasets to Determine Periodontitis Diagnostic Biomarkers and Drug Target Candidates.International journal of molecular sciences · 2022Pooled it
- Magnetic nanohydroxyapatite-peptide silk fibroin hydrogel induces osteogenesis in canine periodontal ligament stem cells revealed by proteomic analysis.The veterinary quarterly · 2026Article
- Curriculum Gaps in Periodontal Knowledge Among Medical Students: A Cross-Sectional Study.European journal of dental education : official journal of the Association for Dental Education in Europe · 2026Article
- Gingival Crevicular Fluid Levels of Parathyroid Hormone-Related Protein, RANK Ligand, and Osteoprotegerin in Periodontal Health, Gingivitis, and Periodontitis: A Cross-Sectional Study.Journal of clinical medicine · 2026Article
- Design and applications of barrier membranes for guided bone regeneration.Bioactive materials · 2026Review
- Oral Piercing in the Aspect of Periodontal and Dental Health-A Narrative Review.Journal of clinical medicine · 2026Review
- Mitochondrial dysfunction in peri-implantitis: bioinformatics and machine learning analysis with in vivo experiment.Odontology · 2026Article
- Salivary osteocalcin as a biomarker for periodontal disease progression and treatment response: a prospective longitudinal study.The Saudi dental journal · 2026Article
- Article
- ROR2 preserves alveolar bone homeostasis by orchestrating IRAK4-dependent suppression of CXCL8-driven osteolysis.Cell communication and signaling : CCS · 2026Article
- Laser-Based Photobiomodulation for Orthodontic Pain: Mechanistic Evidence from Experimental Tooth-Movement Models.International journal of molecular sciences · 2026Review
- B10 Adoptive Transfer Ameliorates Inflammation and Bone Loss in Experimental Periodontitis Through Promoting Macrophage-Mediated Pro-Resolving Functions.Inflammation · 2026Article
- Fermentation time Determines Anti-inflammatory and Osteoprotective Activity of Green Tea Kombucha in a Rat Model of Experimental Periodontitis.Probiotics and antimicrobial proteins · 2026Article
- Geranylgeraniol promotes osteoblast differentiation and inhibits osteoclastogenesis through MAPK and nuclear receptor signaling.The Journal of biological chemistry · 2026Article
- Silymarin inhibits osteoclastogenesis and alleviates inflammatory injury in RAW264.7 cells via activating the AMPK/Sirt1-autophagy axis.Scientific reports · 2026Article
- Identification of hub genes and molecular networks involved in alveolar bone resorption based on bioinformatics analysis.Scientific reports · 2026Article
- Proliferative verrucous leukoplakia management requires x-ray surveillance. A retrospective study of 78 cases.Clinical oral investigations · 2026Article
- Association of Vitamin D Receptor Gene Polymorphisms with Periodontitis.Journal of dentistry (Shiraz, Iran) · 2026Article
299 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Alveolar bone loss is a hallmark of periodontitis progression and its prevention is a key clinical challenge in periodontal disease treatment. Bone destruction is mediated by the host immune and inflammatory response to the microbial challenge. However, the mechanisms by which the local immune response against periodontopathic bacteria disturbs the homeostatic balance of bone formation and resorption in favour of bone loss remain to be established. The osteoclast, the principal bone resorptive cell, differentiates from monocyte/macrophage precursors under the regulation of the critical cytokines macrophage colony-stimulating factor, RANK ligand, and osteoprotegerin. TNF-α, IL-1, and PGE2 also promote osteoclast activity, particularly in states of inflammatory osteolysis such as those found in periodontitis. The pathogenic processes of destructive inflammatory periodontal diseases are instigated by subgingival plaque microflora and factors such as lipopolysaccharides derived from specific pathogens. These are propagated by host inflammatory and immune cell influences, and the activation of T and B cells initiates the adaptive immune response via regulation of the Th1-Th2-Th17 regulatory axis. In summary, Th1-type T lymphocytes, B cell macrophages, and neutrophils promote bone loss through upregulated production of proinflammatory mediators and activation of the RANK-L expression pathways.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.