ArticleBioMed research international2015
Vitamin D Binding Protein Is Not Involved in Vitamin D Deficiency in Patients with Chronic Kidney Disease.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Vitamin D binding protein induces skeletal muscle atrophy and contributes to cancer-associated muscle wasting independently of vitamin D status in preclinical models.Nature communications · 2026Article
- The vitamin D spectrum: insights into 25(OH)D and VDBP in chronic kidney disease and post-transplant.Scientific reports · 2025Article
- A new SOFrontiers in physiology · 2025Article
- Exploring potential multiple molecular biomarkers that predict treatment response in patients with lupus nephritis.Scientific reports · 2024Article
- Vitamin D binding protein correlate with estrogen increase after administration of human chorionic gonadotropin but do not affect ovulation, embryo, or pregnancy outcomes.Frontiers in endocrinology · 2024Observational
- Measurement of Urinary Gc-Globulin by a Fluorescence ELISA Technique: Method Validation and Clinical Evaluation in Septic Patients-A Pilot Study.Molecules (Basel, Switzerland) · 2023Article
- Association between Serum 25-Hydroxyvitamin D and Abdominal Aortic Calcification: A Large Cross-Sectional Study.International journal of clinical practice · 2023Article
- The Role of Vitamin D and Vitamin D Binding Protein in Chronic Liver Diseases.International journal of molecular sciences · 2022Review
- Stage II of Chronic Kidney Disease-A Tipping Point in Disease Progression?Biomedicines · 2022Article
- The Progress of the Prevention and Treatment of Vitamin D to Tuberculosis.Frontiers in nutrition · 2022Review
- Differential Effects of 25-Hydroxyvitamin DCells · 2021Article
- Vitamin D and parathyroid hormone status in community-dwelling elderly patients with mild-to-moderate kidney impairment.International urology and nephrology · 2021Article
- Association between vitamin D metabolites, vitamin D binding protein, and proteinuria in dogs.Journal of veterinary internal medicine · 2020Article
- Vitamin D ameliorates adipose browning in chronic kidney disease cachexia.Scientific reports · 2020Article
- In sickness and in health: pivotal role of vitamin D.Biochemia medica · 2020Review
- Free 25-hydroxyvitamin-D concentrations are lower in children with renal transplant compared with chronic kidney disease.Pediatric nephrology (Berlin, Germany) · 2020Article
- Review
- Vitamin D Deficiency in Chronic Kidney Disease: Recent Evidence and Controversies.International journal of environmental research and public health · 2018Review
- Assessment of Vitamin D-Binding Protein and Early Prediction of Nephropathy in Type 2 Saudi Diabetic Patients.Journal of diabetes research · 2018Article
- Vitamin D-Binding Protein Clearance Ratio Is Significantly Associated with Glycemic Status and Diabetes Complications in a Predominantly Vitamin D-Deficient Population.Journal of diabetes research · 2018Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study was designed to evaluate vitamin D status with separate determination of 25-OH D2 and 25-OH D3 and its relationship to vitamin D binding protein (VDBP) in patients with chronic kidney disease (CKD) and long-term haemodialysis patients (HD).
methods45 CKD patients, 103 HD patients, and 25 controls (C) were included. Plasma vitamin D concentrations were determined using chromatography and VDBP in serum and urine in CKD using enzyme immunoassay.
resultsPlasma vitamin D levels were lower in CKD (30.16 ± 16.74 ng/mL) and HD (18.85 ± 15.85 ng/mL) versus C (48.72 ± 18.35 ng/mL), P < 0.0001. 25-OH D3 was the dominant form of vitamin D. Serum VDBP was higher in CKD (273.2 ± 93.8 ug/mL) versus C (222 ± 87.6 ug/mL) and HD (213.8 ± 70.9 ug/mL), P = 0.0003. Vitamin D/VDBP ratio was the highest in C and the lowest in HD; however, there was no correlation between vitamin D and VDBP. Urinary concentration of VDBP in CKD (0.25 ± 0.13 ug/mL) correlated with proteinuria (r = 0.43, P = 0.003).
conclusionsPlasma levels of vitamin D are decreased in CKD patients and especially in HD patients. 25-OH D3 was the major form of vitamin D. Despite urinary losses of VDBP, CKD patients had higher serum VDBP concentrations, indicating compensatory enhanced production. Vitamin D binding protein is not involved in vitamin D deficiency.
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