ArticleBioMed research international2015
The Characteristics of Antioxidant Activity after Liver Transplantation in Biliary Atresia Patients.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Protective effects of astaxanthin on BDL-induced liver fibrosis: regulating MRP3 and AQP8 in cholestatic rats.Pediatric surgery international · 2026Article
- Infants with biliary atresia exhibit an altered amino acid profile in their newborn screening.Metabolomics : Official journal of the Metabolomic Society · 2024Article
- Perioperative reactive oxygen species in infants with biliary atresia: A retrospective observational study.Medicine · 2020Observational
- Article
- Mitochondrial Mutations in Cholestatic Liver Disease with Biliary Atresia.Scientific reports · 2018Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeCholestatic liver injury is associated with a high production of free radicals. The pathogenesis of liver injury in biliary atresia (BA) patients is largely undefined. The goal of the present study was to clarify the oxidative damage and the changes in antioxidant enzyme activities that occur during the development of BA and after liver transplantation (LT).
methodsWe enrolled BA patients and control subjects and collected their clinical information. The activities of antioxidant enzymes in BA patients before LT (BA group) and after LT (LT group) were analyzed.
resultsThe number of mitochondrial DNA copies had increased in the LT group compared with the BA group. Similarly, the activity of glutathione peroxidase had increased in the LT group compared with the BA group. The level of glutathione was higher in the LT group than in the BA group. Malondialdehyde levels were decreased in the LT group compared with the BA group.
conclusionsThese data indicate that LT is associated with increased antioxidant enzyme activities and decreased malondialdehyde levels in BA patients. The manipulation of mitochondria-associated antioxidative activity might be an important future management strategy for BA.
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