ArticleBioMed research international2015
Neem (Azadirachta indica A. Juss) Oil to Tackle Enteropathogenic Escherichia coli.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Efficacy and Safety of Neem Oil for the Topical Treatment of Bloodsucking LiceAnimals : an open access journal from MDPI · 2023Article
- Formulation of Neem oil-loaded solid lipid nanoparticles and evaluation of its anti-Toxoplasma activity.BMC complementary medicine and therapies · 2022Article
- In vitro antibacterial activity of nimbolide against Helicobacter pylori.Journal of ethnopharmacology · 2022Article
- The Antimicrobial Potential of the Neem TreeFrontiers in pharmacology · 2022Review
- Article
- Leveraging phytochemicals: the plant phylogeny predicts sources of novel antibacterial compounds.Future science OA · 2019Article
- Status, Antimicrobial Mechanism, and Regulation of Natural Preservatives in Livestock Food Systems.Korean journal for food science of animal resources · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Neem (Azadirachta indica A. Juss) oil (NO) was assayed against forty-eight isolates of Escherichia coli by standardised disc diffusion test and microdilution test. By molecular biology characterization, fourteen isolates resulted in diarrheagenic E. coli with sixteen primer pairs that specifically amplify unique sequences of virulence genes and of 16S rRNA. The NO showed biological activity against all isolates. The bacterial growth inhibition zone by disc diffusion method (100 µL NO) ranged between 9.50 ± 0.70 and 30.00 ± 1.00 mm. The antibacterial activity was furthermore determined at lower NO concentrations (1 : 10-1 : 10,000). The percent of growth reduction ranged between 23.71 ± 1.00 and 99.70 ± 1.53. The highest bacterial growth reduction was 1 : 10 NO concentration with 50 µL of bacterial suspension (ca. 1 × 10(6) CFU/mL). There is significant difference between the antibacterial activities against pathogenic and nonpathogenic E. coli, as well as NO and ciprofloxacin activities. Viable cells after the different NO concentration treatments were checked by molecular biology assay using PMA dye. On the basis of the obtained results, NO counteracts E. coli and also influences the virulence of E. coli viable cells after NO treatment. The NO metabolomic composition was obtained using fingerprint HPTLC.
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Registered trials
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