ArticleBioMed research international2015
Development of a Model of Chronic Kidney Disease in the C57BL/6 Mouse with Properties of Progressive Human CKD.
Article in BioMed research international, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 13 citations in OpenAlex.
- Trans fatty acids alter renal health in TGFβ3 mice with fibrosis revealed by metabolomics and lipidomics.iScience · 2026Article
- Jingtian granule alleviates adenine-induced renal fibrosis in mice through SIRT3-Mediated deacetylation of P53.Frontiers in pharmacology · 2025Article
- Renal angiotensin I-converting enzyme-deficient mice are protected against aristolochic acid nephropathy.Pflugers Archiv : European journal of physiology · 2023Article
- Protective effects of endothelial progenitor cell microvesicles carrying miR‑98‑5p on angiotensin II‑induced rat kidney cell injury.Experimental and therapeutic medicine · 2022Article
- Protective effects of endothelial progenitor cell microvesicles on Ang II‑induced rat kidney cell injury.Molecular medicine reports · 2022Article
- TDAG51 induces renal interstitial fibrosis through modulation of TGF-β receptor 1 in chronic kidney disease.Cell death & disease · 2021Article
- Mouse Models of Heart Failure with Preserved or Reduced Ejection Fraction.The American journal of pathology · 2020Review
- Angiotensin II triggers RIPK3-MLKL-mediated necroptosis by activating the Fas/FasL signaling pathway in renal tubular cells.PloS one · 2020Article
- Euthanasia via COMolecular reproduction and development · 2019Article
- Chronic kidney disease-associated cardiovascular disease: scope and limitations of animal models.Cardiovascular endocrinology · 2017Review
- Desoxycorticosterone pivalate-salt treatment leads to non-dipping hypertension in Per1 knockout mice.Acta physiologica (Oxford, England) · 2017Article
- Endoplasmic reticulum stress inhibition attenuates hypertensive chronic kidney disease through reduction in proteinuria.Scientific reports · 2017Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Chronic kidney disease (CKD) is a major healthcare problem with increasing prevalence in the population. CKD leads to end stage renal disease and increases the risk of cardiovascular disease. As such, it is important to study the mechanisms underlying CKD progression. To this end, an animal model was developed to allow the testing of new treatment strategies or molecular targets for CKD prevention. Many underlying risk factors result in CKD but the disease itself has common features, including renal interstitial fibrosis, tubular epithelial cell loss through apoptosis, glomerular damage, and renal inflammation. Further, CKD shows differences in prevalence between the genders with premenopausal women being relatively resistant to CKD. We sought to develop and characterize an animal model with these common features of human CKD in the C57BL/6 mouse. Mice of this genetic background have been used to produce transgenic strains that are commercially available. Thus, a CKD model in this strain would allow the testing of the effects of numerous genes on the severity or progression of CKD with minimal cost. This paper describes such a mouse model of CKD utilizing angiotensin II and deoxycorticosterone acetate as inducers.
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