Evidence map›Paper›PMID 26064774›Full record

ArticleInternational journal of inflammation2015

Influence of Body Mass Index on Inflammatory Profile at Admission in Critically Ill Septic Patients.

Fernando G Zampieri, Vanessa Jacob, Hermes V Barbeiro, Fabiano Pinheiro da Silva, Heraldo P de Souza

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In one paragraph

Article in International journal of inflammation, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Fernando G ZampieriMedical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil ; Intensive Care Unit, Emergency Medicine Discipline, Hospital das Clínicas, University of São Paulo, 05403-010 São Paulo, SP, Brazil ; Intensive Care Unit, Hospital Alemão Oswaldo Cruz, 01323-020 São Paulo, SP, Brazil.
Vanessa JacobMedical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil.
Hermes V BarbeiroMedical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil.
Fabiano Pinheiro da SilvaMedical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil.ORCID 0000-0003-2673-2202
Heraldo P de SouzaMedical Investigation Laboratory 51 (LIM-51), Emergency Medicine Discipline, Faculty of Medicine, University of São Paulo, 01246903 São Paulo, SP, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction. Inflammation is ubiquitous during sepsis and may be influenced by body mass index (BMI). We sought to evaluate if BMI was associated with serum levels of several cytokines measured at intensive care unit admission due to sepsis. Methods. 33 septic patients were included. An array of thirty-two cytokines and chemokines was measured using Milliplex technology. We assessed the association between cytokine levels and BMI by generalized additive model that also included illness severity (measured by SAPS 3 score); one model was built for each cytokine measured. Results. We found that levels of epidermal growth factor, vascular endothelial growth factor, and interleukins 4, 5, and 13 were associated with BMI in a complex, nonlinear way, independently of illness severity. Higher BMI was associated with higher levels of anti-inflammatory interleukins. Conclusion. BMI may influence host response to infection during critical illness. Larger studies should confirm these findings.

Identifiers

PMID26064774
PMCPMC4441988

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.