ArticleInternational journal of clinical and experimental medicine2015
Clinical features of systemic cancer patients with acute cerebral infarction and its underlying pathogenesis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 13 citations in OpenAlex.
- [Cancer-associated stroke: a study of prevalence and predictors among ischaemic stroke patients].Revista de neurologia · 2023Article
- Association between three-territory sign and prognosis of acute ischemic stroke patients with malignancy.Frontiers in neurology · 2023Article
- Cancer-related stroke: Exploring personalized therapy strategies.Brain and behavior · 2022Review
- Distinction in Prevalence of Atherosclerotic Embolic Sources in Cryptogenic Stroke With Cancer Status.Journal of the American Heart Association · 2021Article
- Three Territory Sign: An MRI marker of malignancy-related ischemic stroke (Trousseau syndrome).Neurology. Clinical practice · 2019Article
- Clinical Characteristics and Risk Factors of Lung Cancer-Associated Acute Ischemic Stroke.BioMed research international · 2019Article
- Potential Pathogenesis and Biomarkers of Kidney Cancer-Related Stroke.Medical science monitor : international medical journal of experimental and clinical research · 2017Article
- Three-Territory DWI Acute Infarcts: Diagnostic Value in Cancer-Associated Hypercoagulation Stroke (Trousseau Syndrome).AJNR. American journal of neuroradiology · 2016Article
- Stroke and a valvular lesion in a patient with stage IV non-small cell lung cancer.BMJ case reports · 2016Article
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe increased incidence of cerebral infarction in patients with systemic cancer has been reported; however, the underline mechanisms remain unclear. Investigation regarding the clinical features of cerebral infarction in cancer patients could be helpful to understand its underlying pathogenesis.
methodsA total of 537 patients were recruited and divided into three groups: 1) stroke and cancer group (SCG), defined as active cancer patients with acute cerebral infarction; 2) stroke group (SG), defined as acute cerebral infarction patients without cancer; and 3) Cancer group (CG), defined as active cancer patients without cerebral infarction. These patients were age and gender-matched among groups.
results179 patients, including 128 male subjects (73.68%) were enrolled in each group. Compared to SG patients, more SCG patients lacked conventional vascular risk factors (CRFs), and had elevated plasma D-dimer, cancer antigen (CA) 125 and 199 levels with multiple lesions in multiple cerebral arterial territories. In addition, SCG patients were found to have poorer prognosis. Compared to CG patients, more SCG patients' cancer had metastasized. Multiple logistic regression analysis showed that the elevated plasma D-dimer, CA125 and CA199 levels may independently increase, but chemoradiotherapy decreased the risk of cerebral infarction in cancer patients.
conclusionsOur study demonstrated that the clinical features of acute cerebral infarction in most active cancer patients can be identified as multiple lesions in multiple cerebral arterial territories with elevated plasma D-dimer and the elevated levels of cancer antigens.
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26064369PMC4443203W592442012What OpenQuestion holds
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