ArticleInternational journal of clinical and experimental medicine2015
Relationship between thioredoxin-interacting protein (TXNIP) and islet β-cell dysfunction in patients with impaired glucose tolerance and hypertriglyceridemia.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- Thioredoxin-interacting protein is associated with obesity-induced insulin resistance in PCOS patients: a large-scale case-control study.Archives of gynecology and obstetrics · 2025Article
- Changes in plasma IRAK-M in patients with prediabetes and its relationship with related metabolic indexes: a cross-sectional study.The Journal of international medical research · 2022Article
- MicroRNA‑532‑5p regulates oxidative stress and insulin secretion damage in high glucose‑induced pancreatic β cells by downregulating the expression levels of CCND1.Molecular medicine reports · 2021Article
- miR-720 Regulates Insulin Secretion by Targeting Rab35.BioMed research international · 2021Article
- Early Predictors in the Onset of Type 2 Diabetes at Different Fasting Blood Glucose Levels.Diabetes, metabolic syndrome and obesity : targets and therapy · 2021Article
- Circulating miR-130 and its target PPAR-γ may be potential biomarkers in patients of coronary artery disease with type 2 diabetes mellitus.Molecular genetics & genomic medicine · 2019Article
- Antipsychotic inductors of brain hypothermia and torpor-like states: perspectives of application.Psychopharmacology · 2017Review
- Activation of NLRP3 Inflammasome by Advanced Glycation End Products Promotes Pancreatic Islet Damage.Oxidative medicine and cellular longevity · 2017Article
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
aimsTo study the relationship between thioredoxin-interacting protein (TXNIP) and pancreatic β-cell function in patients with impaired glucose regulation and patients with both impaired glucose regulation and hypertriglyceridemia.
methodsWe analyzed a population of 90 patients with impaired glucose regulation (IGR), 87 patients with IGR and hypertriglyceridemia, and 90 subjects with normal glucose tolerance (NGT). The levels of plasma TXNIP, a regulator of cellular oxidative stress, were measured. The homeostasis model assessment for insulin resistance (HOMA-IR) was used to evaluate insulin resistance in all subjects. In addition, two factors (HOMA for β-cell function [HOMA-β]) and first-phase insulin response [FPIR]) were used to evaluate pancreatic β-cell function. The correlations between the plasma levels of TXNIP, insulin resistance, and islet β-cell dysfunction were analyzed using Pearson's correlation analysis.
resultsCompared with NGT, patients with IGR had significantly lower HOMA-β and FPIR, and higher plasma levels of TXNIP. Compared with the IGR group, patients with both IGR and hypertriglyceridemia had significantly lower HOMA-β and FPIR, and higher plasma levels of TXNIP. There was also a negative correlation between TXNIP and HOMA-β or FPIR, and a positive correlation between TXNIP and HOMA-IR.
conclusionsThese data showed that the level of TXNIP is increased in patients with IGR and patients with both IGR and hypertriglyceridemia, islet β-cell dysfunction was related to the increased TXNIP in IGR patients.
Indexed as
Identifiers
26064354PMC4443188W2416722769What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.