ArticleInternational journal of clinical and experimental medicine2015
Predictive model of portal venous system thrombosis in cirrhotic portal hypertensive patients after splenectomy.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
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Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 25 citations in OpenAlex.
- Splanchnic Vein Thrombosis in Liver Cirrhosis After Splenectomy or Splenic Artery Embolization: A Systematic Review and Meta-Analysis.Advances in therapy · 2021Pooled it
- Predictive Effect of Mean Platelet Volume in Patients with Portal Vein Thrombosis: A Meta-analysis of Case-control Studies.Current medical science · 2018Pooled it
- [Construction and validation of a nomogram for predicting the risk of portal vein thrombosis after splenectomy in patients with hepatitis B cirrhosis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2020Trial
- Textbook outcomes after splenectomy in patients with portal hypertension.Scientific reports · 2025Article
- Nomogram-based prediction of portal vein system thrombosis formation after splenectomy in patients with hepatolenticular degeneration.Frontiers in medicine · 2023Article
- Early prevention and risk factors analysis of portal vein system thrombosis after laparoscopic splenectomy and pericardial devascularization.Surgical endoscopy · 2022Article
- Research Progress in Chinese Medicine Preparations for Promoting Blood Circulation and Removing Blood Stasis for Cirrhotic Patients with Portal Vein Thrombosis Following Splenectomy.Chinese journal of integrative medicine · 2022Review
- Living donor liver transplantation combined with splenectomy in a child with Niemann-Pick disease type B: single-centre experience of perioperative anticoagulation regimen.Hepatobiliary surgery and nutrition · 2022Article
- Evaluation of Platelet Indices in Patients with Splanchnic Vein Thrombosis.Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion · 2021Article
- Nomogram Model for Prediction of Portal Vein Thrombosis in Patients with Liver Cirrhosis After Splenectomy: A Retrospective Analysis of 2 Independent Cohorts.Medical science monitor : international medical journal of experimental and clinical research · 2021Article
- Prediction of the Factors Influencing the Shengjing Classification of Portal Vein Thrombosis after Splenectomy for Portal Hypertension in Cirrhosis: A Single-Center Retrospective Case-Control Study.BioMed research international · 2020Article
- Risk Factors of Portal Vein Thrombosis after Devascularization Treatment in Patients with Liver Cirrhosis: A Nested Case-Control Study.BioMed research international · 2020Article
- A novel method detecting the key clinic factors of portal vein system thrombosis of splenectomy & cardia devascularization patients for cirrhosis & portal hypertension.BMC bioinformatics · 2019Article
- Effects of early antiplatelet therapy after splenectomy with gastro-oesophageal devascularization.ANZ journal of surgery · 2018Article
- Association Between Changes in Splanchnic Hemodynamics and Risk Factors of Portal Venous System Thrombosis After Splenectomy with Periesophagogastric Devascularization.Medical science monitor : international medical journal of experimental and clinical research · 2018Article
- Article
- The causes of lower-extremity deep venous thrombosis in the children with cranial diseases.International journal of clinical and experimental medicine · 2015Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study is to investigate the risk factors of portal venous system thrombosis (PVT) in patients with cirrhotic portal hypertension after splenectomy and to establish a Logistic regression prediction model.
methodsA total of 119 patients with cirrhotic portal hypertension were enrolled. Their clinical data was retrospectively analyzed. They were divided into PVT group (n = 18) and non-PVT group (n = 101). One-way analysis and multivariate Logistic regression analysis were performed to analyze the independent risk factors of PVT. Logistic regression prediction model was established. The receiver operating characteristic curve was generated and correlation analysis was conducted.
resultsPlatelet count (PLT), mean platelet volume (MPV) and D-Dimer were independent risk factors affecting PVT. Anticoagulation therapy (UAT) and usage of reducing portal pressure therapy (URPT) were independent protective factors of PVT. Logistic regression prediction model was expressed as Logit P = -9.165 + 0.664 × PLT (× 10(11)/L) + 0.413 × MPV (fL) + 0.662 × D-Dimer (mg/L) -1.674 × UAT (Yes = 1, No = 0) -1.518 × URPT (Yes = 1, No = 0). And, the cut-off value of Logit P was -1.14. The area under the receiver operating characteristic curve and the accuracy were 0.865 and 84.03%. The cut-off value of PLT, MPV and D-Dimer were 4.42 × 10(11)/L, 13.30 fL and 2.55 mg/L, respectively. MPV and D-Dimer were positively correlated.
conclusionPLT, MPV and D-Dimer are independent risk factors while UAT and URPT are independent protective factors of PVT. Logistic regression prediction model can predict PVT with a high sensitivity, specificity and accuracy. It provides theoretical foundation and cut-off value for predicting PVT after splenectomy.
Indexed as
Identifiers
26064335PMC4443169W2413962687What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.