ArticleInternational journal of clinical and experimental medicine2015
The variance of peripheral blood lymphocyte subsets of streptozotocin-induced diabetic mice after bone marrow transplantation.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed, 5 citations in OpenAlex.
- Circulating Monocyte and Lymphocyte Populations in Healthy First-Degree Relatives of Type 2 Diabetic Patients at Fasting and during Short-Term Hyperinsulinemia.Mediators of inflammation · 2019Article
- The effect of swimming exercise and powdered-Salicornia herbacea L. ingestion on glucose metabolism in STZ-induced diabetic rats.Journal of exercise nutrition & biochemistry · 2015Article
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Authors and funding
4 authors at 1 institution in 1 country.
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Abstract
Type 1 diabetes (T1D) results from the host immune disorder, which elicits the selective destruction of insulin-producing s in the pancreatic islets. Bone marrow transplantation (BMT) has been reported to treat T1D in numerous studies, and has been proved to be effective in treating T1D based on immune ablation and regeneration. In this study, we aimed to evaluate the curative effect of syngeneic bone marrow transplantation (syn-BMT) and to analyze peripheral blood lymphocyte phenotypes of streptozotocin (STZ)-induced diabetic mice after syn-BMT, and further to reveal possible mechanisms of syn-BMT involved in normalization of blood glucose. After multiple injections of low-dose STZ, most male C57BL/6J inbred mice got hyperglycemia, and then underwent syn-BMT. Fasting blood glucose was detected every 10 days after syn-BMT. The hemocytes count was evaluated every 3 days after syn-BMT in mice. Before syn-BMT, and on days 30, 60, and 90 after syn-BMT, we examined proportion of peripheral blood T lymphocytes, CD19(+) B lymphocytes, and NK cells by flow cytometry. Our data showed that hyperglycemia could be reversed and normal blood glucose level could be maintained in the whole observation period after syn-BMT. The peripheral blood elevated CD4(+)/CD8(+) T lymphocyte ratio, CD19(+) B lymphocyte proportion and NK cell proportion in diabetic mice significantly decreased after syn-BMT. This study indicated that syn-BMT could reverse hyperglycemia and revealed immune ablation and immune system regeneration might be a possible mechanism of syn-BMT involved in normalization of blood glucose.
Indexed as
Identifiers
26064318PMC4443152W648208747What OpenQuestion holds
Registered trials
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