Evidence map›Paper›PMID 26064316›Full record

ArticleInternational journal of clinical and experimental medicine2015

Protection by LPS-induced inhibitory CD11b(+) cells on corneal allograft.

Yuping Han, Shaozhen Zhao

Open access · greenAbstract read
PubMed Full text at PMC
In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 44% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Yuping HanDepartment of Corneal and Refractive Disease, Tianjin Medical University Eye Hospital Tianjin 300384, P. R. China ; Department of Corneal Disease, Shanxi Eye Hospital Taiyuan 030002, Shanxi, P. R. China.
Shaozhen ZhaoDepartment of Corneal and Refractive Disease, Tianjin Medical University Eye Hospital Tianjin 300384, P. R. China.
Shanxi Eye Hospital · CNTianjin Medical University Eye Hospital · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveIt is widely reported that CD11b(+)Gr1+ myeloid-derived suppressor cells can cause allograft tolerance in mice and human, however, little is known on the therapy role in chronic transplantation rejection. In this paper, their role in corneal transplantation was studied for the first time.

methodInhibitory CD11b(+) cells were obtained by murine LPS-induced septic model. Phenotype, endocytosis, antigen presenting ability, and T cell suppression assays were performed by flow cytometry analysis. The suppressive ability in vivo was analyzed by targeting allogeneic corneal transplantation.

resultsLPS was intraperitoneally injected into C57BL/6 mice, the percentage of CD11b(+) Gr1+ cells was increased in mice spleen, blood, and bone marrow, respectively. Compared with control mice, Ly6C, TLR2, and MHC-11 expression were higher in LPS treated mice. CD11b(+) Gr1+ cells could inhibit allogenic corneal reaction in vivo after adoptive transfer, in consistent with an observation of inhibition effect on the antigen presenting cells (APCs) and CD4+ T cells proliferation in vitro.

conclusionCD11b(+) cells induced by LPS could function as inhibitory APCs, suppress CD4+ T cells proliferation and improve corneal allograft survival. Predictly, its application for cells transfer therapy in clinic in the further.

Indexed as

CD11b+corneal transplantationLPS

Identifiers

PMID26064316
PMCPMC4443150
OpenAlexW2437116674

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.