ArticleInternational journal of clinical and experimental medicine2015
Down-regulation of microRNA-26b rescued hypoxia-induced apoptosis in cultured neonatal rat cardiac myocytes by regulating PTEN.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- The role of Mir-365-5p in regulating NF2-Mediated apoptosis and ROS production in hypoxic cardiomyoblasts.Molecular biology reports · 2025Article
- Cardiac biopsies reveal differences in transcriptomics between left and right ventricle in patients with or without diagnostic signs of heart failure.Scientific reports · 2024Article
- MicroRNA-26b inhibits cardiac remodeling after myocardial infarction by targeting ring finger protein 6 expression.Archives of medical science : AMS · 2024Article
- Effect of HIF-1α/miR-10b-5p/PTEN on Hypoxia-Induced Cardiomyocyte Apoptosis.Journal of the American Heart Association · 2019Article
- LncRNA260-specific siRNA targetingJournal of thoracic disease · 2017Article
- A novel hypoxia-induced miR-147a regulates cell proliferation through a positive feedback loop of stabilizing HIF-1α.Cancer biology & therapy · 2016Article
- Regulation of proliferation, angiogenesis and apoptosis in hepatocellular carcinoma by miR-26b-5p.Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine · 2016Article
- Conserved miR-26b enhances ovarian granulosa cell apoptosis through HAS2-HA-CD44-Caspase-3 pathway by targeting HAS2.Scientific reports · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundCardiomyocyte hypoxia causes cardiac hypertrophy and other major myocardial injuries. We investigated the molecular mechanism of microRNA-26b (miR-26b) in regulating hypoxia-induced apoptosis in rat neonatal cardiomyocytes.
methodsNeonatal rat cardiomyocytes was prepared in vitro and hypoxia was induced. Apoptotic cardiomyocytes were examined by TUNEL staining and the expression of miR-26b were monitored by qRT-PCR. The effect of mir-26b downregulation on hypoxia-induced apoptosis, or expression of PTEN in cardiomyocytes was monitored. PTEN was knocked down in cardiomyocytes by siRNA to further investigate its association with miR-26b.
resultsHypoxia induced severe apoptosis and upregulated miR-26b in neonatal rat cardiomyocytes in vitro. Down-regulation of miR-26b markedly ameliorated hypoxia-induced apoptosis and up-regulated PTEN. Luciferase reporter assay confirmed PTEN was directly targeted by miR-26b, and knocking down PTEN reduced cytotoxicity induced by miR-26b upregulation.
conclusionDownregulation of miR-26b protected cardiomyocytes from hypoxia-induced apoptosis, and the protective effect was very likely to be associated with PTEN regulation.
Indexed as
Identifiers
26064312PMC4443146W2415493846What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.