ArticleInternational journal of clinical and experimental medicine2015
Changes of serum TNF-α, IL-5 and IgE levels in the patients of mycoplasma pneumonia infection with or without bronchial asthma.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 11 citations in OpenAlex.
- Diagnostic value of cytokines in severe childhood Mycoplasma pneumoniae pneumonia combined with Adenovirus infection.Italian journal of pediatrics · 2024Article
- Metabolism Characteristics ofAllergy, asthma & immunology research · 2022Article
- Efficacy of human immunoglobulin injection and effects on serum inflammatory cytokines in neonates with acute lung injury.Experimental and therapeutic medicine · 2021Article
- Clinical Efficacy of Methotrexate Combined with Iguratimod on Patients with Rheumatoid Arthritis and Its Influence on the Expression Levels of HOTAIR in Serum.BioMed research international · 2021Article
- Serum Cytokines and FeNO in School-Aged Children with Mycoplasma pneumoniae Pneumonia.Medical science monitor : international medical journal of experimental and clinical research · 2020Article
- Lung Microbiota and Pulmonary Inflammatory Cytokines Expression Vary in Children With Tracheomalacia and Adenoviral orFrontiers in pediatrics · 2019Article
- The Immunopathologic Effects of Mycoplasma pneumoniae and Community-acquired Respiratory Distress Syndrome Toxin. A Primate Model.American journal of respiratory cell and molecular biology · 2018Article
- High immunoglobulin E level is associated with increased readmission in children with bronchopneumonia.Therapeutic advances in respiratory diseaseArticle
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to investigate the changes of serum levels of TNF-α, IL-5 and IgE in mycoplasma pneumonia (MP) infection patients with or without bronchial asthma and explore its clinical importance.
methodsELISA and Western blot assay were performed to detect the serum levels of TNF-α, IL-5 and IgE in 35 healthy subjects, 45 patients with MP infection and 40 bronchial asthma patients with MP infection.
resultsThe serum levels of TNF-α, IL-5 and IgE in MP infection patients and asthma patients with MP infection were significantly higher than those in healthy subjects (P<0.01). Moreover, the serum levels of TNF-α, IL-5 and IgE in asthma patients with MP infection was markedly higher than those in MP infection patients (P<0.05). Correlation analysis showed serum TNF-α was positively associated with serum IL-5 (r=0.9636, P<0.01), serum TNF-α positively related to IgE (r=0.9841, P<0.01) and serum IgE positively relevant with serum IL-5 (r=0.9572, P<0.01) in asthma patients with MP infection.
conclusionOur findings indicate that serum levels of TNF-α, IL-5 and IgE may play important roles in the pathogenesis of MP infection, especially in asthma patients.
Indexed as
Identifiers
26064291PMC4443125W2395739778What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.