Osteopontin can decrease the cartilage cellular inflammatory reaction induced by LPS.

Fengsheng Li, Dongping Ye, Jun Duan, Hao Sun

Open access · greenAbstract read

In one paragraph

Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 73% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 1 citations in OpenAlex.

Potential Targeting Mechanisms for Bone-Directed Therapies.International journal of molecular sciences · 2024
Review

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Fengsheng LiGuangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Medical College, Jinan University Guangzhou 510220, P. R. China.

Dongping YeGuangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Medical College, Jinan University Guangzhou 510220, P. R. China.

Jun DuanGuangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Medical College, Jinan University Guangzhou 510220, P. R. China.

Hao SunGuangzhou Institute of Traumatic Surgery, Guangzhou Red Cross Hospital, Medical College, Jinan University Guangzhou 510220, P. R. China.

Jinan University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aims to explore the effect of osteopontin on the inflammatory reaction of cartilage cells stimulated by LPS and its possible signal pathway.

methodsThe inflammatory reaction of cartilage cells was induced by LPS, and then the cells were treated with OPN and PD98059 respectively. The expression of TNF-α, IL-1β and ERK1/2 were detected by ELISA or Western-blotting methods.

resultsOsteopontin could decrease the cartilage cellular inflammatory reaction induced by LPS with dose dependent, while PD98059 could reverse the inhibition of osteopontin.

conclusionOsteopontin could decrease the cartilage cellular inflammatory reaction induced by LPS, which may be associated with the ERK1/2 signal pathway.

Indexed as

ERK1/2 signal pathwayinflammatory reactionOsteopontin

Identifiers

PMID26064289

PMCPMC4443123

OpenAlexW2418984725

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.