ArticleInternational journal of clinical and experimental medicine2015
CCDC26 rs4295627 polymorphism and glioma risk: a meta-analysis.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it, 5 citations in OpenAlex.
- The role of the RTEL1 rs2297440 polymorphism in the risk of glioma development: a meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2016Pooled it
- The immune cell infiltration-associated molecular subtypes and gene signature predict prognosis for osteosarcoma patients.Scientific reports · 2024Article
- Replication of GWAS identifies RTEL1, CDKN2A/B, and PHLDB1 SNPs as risk factors in Portuguese gliomas patients.Molecular biology reports · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Several studies have examined the association of CCDC26 rs4295627 polymorphism and glioma risk. However, the results were conflicting. Thus, a meta-analysis was conducted. We searched for relevant studies up to Dec 2014 in both English and Chinese through the PubMed/MEDLINE, EMBASE, the China National Knowledge Infrastructure (CNKI) platforms, WanFang and VIP database. Overall, 14 studies with 17419 cases and 28465 controls were selected for final meta-analysis. CCDC26 rs4295627 polymorphism was significantly associated with an increased risk of glioma (OR = 1.25, 95% CI 1.15-1.36, P < 0.00001). Interestingly, CCDC26 rs4295627 polymorphism might decrease the risk of glioma in Asians (OR = 0.92, 95% CI 0.82-1.03, P = 0.15). However, Caucasians with CCDC26 rs4295627 polymorphism showed an increased risk of glioma (OR = 1.33, 95% CI 1.25-1.46, P < 0.00001). Subgroup analysis was performed by histology. Significant associations were observed among astrocytoma patients (OR = 1.31, 95% CI 1.17-1.47, P < 0.00001) and oligodendroglioma patients (OR = 1.79, 95% CI 1.47-2.17, P < 0.00001). No significant association was found between this polymorphism and glioblastoma risk (OR = 0.11, 95% CI 0.92-1.33, P = 0.28). This meta-analysis suggested that CCDC26 rs4295627 polymorphism was a risk factor for glioma.
Indexed as
Identifiers
26064285PMC4443119W2408912202What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.