ArticleInternational journal of clinical and experimental medicine2015
Carriage of NBN polymorphisms and acute leukemia risk.
Article in International journal of clinical and experimental medicine, 2015. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed, 2 citations in OpenAlex.
- Association of DNA repair genes polymorphisms with childhood acute lymphoblastic leukemia: a high-resolution melting analysis.BMC research notes · 2022Article
- Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundRecent reports revealed a significant association of NBN polymorphisms with risk of acute leukemia among Chinese, but not among Europeans. The objective of this study was to obtain a more precise measure of acute leukemia risk associated with NBN rs1805794, rs2735383, rs709816 polymorphisms.
methodsUsing PubMed, Embase, ISI Web of Science, and the Cochrane Library databases, we undertook a systematic literature search up to September 1, 2014. Eligible studies were singled out from 31 possibly related publications by two investigators. Based on the extracted NBN genotypes, we calculated pooled odds ratios (ORs) and 95% confidence intervals (95% CI) by use of the random effects model proposed by DerSimonian and Laird.
resultsWe finally derived 3,065 subjects for meta-analysis of rs1805794, and found that carriage of the CC genotype was associated with approximately 1.70-fold increased risk of acute leukemia (OR 1.66, 95% CI 1.17-2.36; OR 1.77, 95% CI 1.23-2.54). A 25% higher risk was also identified among the individuals with the C allele (OR 1.25, 95% CI 1.03-1.51). Among 1,553 subjects for rs2735383, no significant association was indicated in the investigated comparison models. Nor did the analysis of 1,485 samples for rs709816 suggest any noteworthy connection.
conclusionsCarriage of rs1805794 polymorphism in the NBN gene may be associated with the occurrence of acute leukemia. New clinical studies are needed to identify the genetic associations and thus facilitates an increased understanding of the molecular mechanisms of this malignancy.
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Identifiers
26064273PMC4443107W2443263698What OpenQuestion holds
Registered trials
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